A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack o...

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Detalles Bibliográficos
Autores principales: Cairney, Claire J., Godwin, Lauren S., Bilsland, Alan E., Burns, Sharon, Stevenson, Katrina H., McGarry, Lynn, Revie, John, Moore, Jon D., Wiggins, Ceri M., Collinson, Rebecca S., Mudd, Clare, Tsonou, Elpida, Sadaie, Mahito, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570495/
https://www.ncbi.nlm.nih.gov/pubmed/28806777
http://dx.doi.org/10.1371/journal.pgen.1006942

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