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Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease

Progranulin (PGRN) is a multifunctional protein that is widely expressed throughout the brain, where it has been shown to act as a critical regulator of CNS inflammation and also functions as an autocrine neuronal growth factor, important for long-term neuronal survival. PGRN has been shown to activ...

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Detalles Bibliográficos
Autores principales: Van Kampen, Jackalina M., Kay, Denis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570501/
https://www.ncbi.nlm.nih.gov/pubmed/28837568
http://dx.doi.org/10.1371/journal.pone.0182896

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