Loss of the chromatin modifier Kdm2aa causes Braf(V600E)-independent spontaneous melanoma in zebrafish

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanoma...

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Detalles Bibliográficos
Autores principales: Scahill, Catherine M., Digby, Zsofia, Sealy, Ian M., Wojciechowska, Sonia, White, Richard J., Collins, John E., Stemple, Derek L., Bartke, Till, Mathers, Marie E., Patton, E. Elizabeth, Busch-Nentwich, Elisabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570503/
https://www.ncbi.nlm.nih.gov/pubmed/28806732
http://dx.doi.org/10.1371/journal.pgen.1006959

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