A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy in Aβ production and AD progression is co...

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Detalles Bibliográficos
Autores principales: Rocchi, Altea, Yamamoto, Soh, Ting, Tabitha, Fan, Yuying, Sadleir, Katherine, Wang, Yigang, Zhang, Weiran, Huang, Sui, Levine, Beth, Vassar, Robert, He, Congcong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570506/
https://www.ncbi.nlm.nih.gov/pubmed/28806762
http://dx.doi.org/10.1371/journal.pgen.1006962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570506/
https://www.ncbi.nlm.nih.gov/pubmed/28806762
http://dx.doi.org/10.1371/journal.pgen.1006962

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