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Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer
Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2 (HER2) is associated with high-grade...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Anti-Cancer Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570603/ https://www.ncbi.nlm.nih.gov/pubmed/28884043 http://dx.doi.org/10.20892/j.issn.2095-3941.2017.0044 |
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author | Chen, Wei Li, Xiaofeng Zhu, Lei Liu, Jianjing Xu, Wengui Wang, Ping |
author_facet | Chen, Wei Li, Xiaofeng Zhu, Lei Liu, Jianjing Xu, Wengui Wang, Ping |
author_sort | Chen, Wei |
collection | PubMed |
description | Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2 (HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer. |
format | Online Article Text |
id | pubmed-5570603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chinese Anti-Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-55706032017-09-07 Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer Chen, Wei Li, Xiaofeng Zhu, Lei Liu, Jianjing Xu, Wengui Wang, Ping Cancer Biol Med Review Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2 (HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer. Chinese Anti-Cancer Association 2017-08 /pmc/articles/PMC5570603/ /pubmed/28884043 http://dx.doi.org/10.20892/j.issn.2095-3941.2017.0044 Text en Copyright 2017 Cancer Biology & Medicine http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Review Chen, Wei Li, Xiaofeng Zhu, Lei Liu, Jianjing Xu, Wengui Wang, Ping Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title_full | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title_fullStr | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title_full_unstemmed | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title_short | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer |
title_sort | preclinical and clinical applications of specific molecular imaging for her2-positive breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570603/ https://www.ncbi.nlm.nih.gov/pubmed/28884043 http://dx.doi.org/10.20892/j.issn.2095-3941.2017.0044 |
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