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Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden

Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of advers...

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Autores principales: Stokkeland, Knut, Ludvigsson, Jonas Filip, Hultcrantz, Rolf, Ekbom, Anders, Höijer, Jonas, Bottai, Matteo, Stephansson, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570776/
https://www.ncbi.nlm.nih.gov/pubmed/28550648
http://dx.doi.org/10.1007/s10654-017-0261-z
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author Stokkeland, Knut
Ludvigsson, Jonas Filip
Hultcrantz, Rolf
Ekbom, Anders
Höijer, Jonas
Bottai, Matteo
Stephansson, Olof
author_facet Stokkeland, Knut
Ludvigsson, Jonas Filip
Hultcrantz, Rolf
Ekbom, Anders
Höijer, Jonas
Bottai, Matteo
Stephansson, Olof
author_sort Stokkeland, Knut
collection PubMed
description Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls. Crude and adjusted relative risks (aRR) were calculated using Poisson regression analysis. Women with HCV were more likely to smoke (46.7 vs. 8.0%) and to have alcohol dependence (18.9 vs. 1.3%) compared with population controls. Most women with HBV were born in non-Nordic countries (91.9%). Maternal HCV was associated with a decreased risk of preeclampsia (aRR: 0.39, 95% CI: 0.24–0.64), but an increased risk of preterm birth (aRR: 1.32, 95% CI: 1.08–1.60) and late neonatal death (7–27 days: aRR: 3.79, 95% CI: 1.07–13.39) Preterm birth were also more common in mothers with HBV, aRR: 1.21 (95% CI: 1.02–1.45). Both HBV and HCV are risk factors for preterm birth, while HCV seems to be associated with a decreased risk for preeclampsia. Future studies should corroborate these findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10654-017-0261-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-55707762017-09-07 Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden Stokkeland, Knut Ludvigsson, Jonas Filip Hultcrantz, Rolf Ekbom, Anders Höijer, Jonas Bottai, Matteo Stephansson, Olof Eur J Epidemiol Perinatal Epidemiology Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls. Crude and adjusted relative risks (aRR) were calculated using Poisson regression analysis. Women with HCV were more likely to smoke (46.7 vs. 8.0%) and to have alcohol dependence (18.9 vs. 1.3%) compared with population controls. Most women with HBV were born in non-Nordic countries (91.9%). Maternal HCV was associated with a decreased risk of preeclampsia (aRR: 0.39, 95% CI: 0.24–0.64), but an increased risk of preterm birth (aRR: 1.32, 95% CI: 1.08–1.60) and late neonatal death (7–27 days: aRR: 3.79, 95% CI: 1.07–13.39) Preterm birth were also more common in mothers with HBV, aRR: 1.21 (95% CI: 1.02–1.45). Both HBV and HCV are risk factors for preterm birth, while HCV seems to be associated with a decreased risk for preeclampsia. Future studies should corroborate these findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10654-017-0261-z) contains supplementary material, which is available to authorized users. Springer Netherlands 2017-05-26 2017 /pmc/articles/PMC5570776/ /pubmed/28550648 http://dx.doi.org/10.1007/s10654-017-0261-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Perinatal Epidemiology
Stokkeland, Knut
Ludvigsson, Jonas Filip
Hultcrantz, Rolf
Ekbom, Anders
Höijer, Jonas
Bottai, Matteo
Stephansson, Olof
Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title_full Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title_fullStr Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title_full_unstemmed Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title_short Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden
title_sort pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in sweden
topic Perinatal Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570776/
https://www.ncbi.nlm.nih.gov/pubmed/28550648
http://dx.doi.org/10.1007/s10654-017-0261-z
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