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The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China

In order to evaluate the impact of assisted reproductive technology (ART) procedure and individual factors on the sex ratio of singletons and twins at birth after in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment in China. We conducted a retrospective cohort study i...

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Autores principales: Chen, Mengxi, Du, Jiangbo, Zhao, Jing, Lv, Hong, Wang, Yifeng, Chen, XiaoJiao, Zhang, Junqiang, Hu, Lingmin, Jin, Guangfu, Shen, Hongbing, Hu, Zhibin, Xiong, Fang, Chen, Li, Ling, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570918/
https://www.ncbi.nlm.nih.gov/pubmed/28839144
http://dx.doi.org/10.1038/s41598-017-06152-9
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author Chen, Mengxi
Du, Jiangbo
Zhao, Jing
Lv, Hong
Wang, Yifeng
Chen, XiaoJiao
Zhang, Junqiang
Hu, Lingmin
Jin, Guangfu
Shen, Hongbing
Hu, Zhibin
Xiong, Fang
Chen, Li
Ling, Xiufeng
author_facet Chen, Mengxi
Du, Jiangbo
Zhao, Jing
Lv, Hong
Wang, Yifeng
Chen, XiaoJiao
Zhang, Junqiang
Hu, Lingmin
Jin, Guangfu
Shen, Hongbing
Hu, Zhibin
Xiong, Fang
Chen, Li
Ling, Xiufeng
author_sort Chen, Mengxi
collection PubMed
description In order to evaluate the impact of assisted reproductive technology (ART) procedure and individual factors on the sex ratio of singletons and twins at birth after in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment in China. We conducted a retrospective cohort study including patients undergoing their first cycle of IVF or ICSI with autologous oocytes from 2001 to 2015. A total of 7410 babies were born from 5832 women with 7410 live birth. The secondary sex ratio (SSR) in singletons was significantly higher than twins (53.97% vs. 50.89%, P = 0.009). The largest disparity was observed in ‘thawed blastocyst embryos ICSI’ subgroup that SSR was 59.84% in singletons and 42.45% in twins (P = 0.013). Blastocyst transfer was positively associated with elevated SSR when compared to cleavage stage embryos in singletons (Odds Ratio [OR] = 1.17, P < 0.001). In addition, paternal age was significantly associated with SSR (OR = 0.75, P = 0.014). While the decrease of SSR was significantly associated with ICSI when compared to IVF (OR = 0.61, P = 0.046) in twins. Blastocyst transfer increases SSR in comparing with cleavage stage embryos in singletons, while the use of ICSI reduces SSR in twins. Our findings offered important complement for better understanding the underlying determinant of SSR in ART offspring.
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spelling pubmed-55709182017-09-01 The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China Chen, Mengxi Du, Jiangbo Zhao, Jing Lv, Hong Wang, Yifeng Chen, XiaoJiao Zhang, Junqiang Hu, Lingmin Jin, Guangfu Shen, Hongbing Hu, Zhibin Xiong, Fang Chen, Li Ling, Xiufeng Sci Rep Article In order to evaluate the impact of assisted reproductive technology (ART) procedure and individual factors on the sex ratio of singletons and twins at birth after in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment in China. We conducted a retrospective cohort study including patients undergoing their first cycle of IVF or ICSI with autologous oocytes from 2001 to 2015. A total of 7410 babies were born from 5832 women with 7410 live birth. The secondary sex ratio (SSR) in singletons was significantly higher than twins (53.97% vs. 50.89%, P = 0.009). The largest disparity was observed in ‘thawed blastocyst embryos ICSI’ subgroup that SSR was 59.84% in singletons and 42.45% in twins (P = 0.013). Blastocyst transfer was positively associated with elevated SSR when compared to cleavage stage embryos in singletons (Odds Ratio [OR] = 1.17, P < 0.001). In addition, paternal age was significantly associated with SSR (OR = 0.75, P = 0.014). While the decrease of SSR was significantly associated with ICSI when compared to IVF (OR = 0.61, P = 0.046) in twins. Blastocyst transfer increases SSR in comparing with cleavage stage embryos in singletons, while the use of ICSI reduces SSR in twins. Our findings offered important complement for better understanding the underlying determinant of SSR in ART offspring. Nature Publishing Group UK 2017-08-24 /pmc/articles/PMC5570918/ /pubmed/28839144 http://dx.doi.org/10.1038/s41598-017-06152-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Mengxi
Du, Jiangbo
Zhao, Jing
Lv, Hong
Wang, Yifeng
Chen, XiaoJiao
Zhang, Junqiang
Hu, Lingmin
Jin, Guangfu
Shen, Hongbing
Hu, Zhibin
Xiong, Fang
Chen, Li
Ling, Xiufeng
The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title_full The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title_fullStr The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title_full_unstemmed The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title_short The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China
title_sort sex ratio of singleton and twin delivery offspring in assisted reproductive technology in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570918/
https://www.ncbi.nlm.nih.gov/pubmed/28839144
http://dx.doi.org/10.1038/s41598-017-06152-9
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