Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound and oncolytic virus therapies also modulate host immune responses in ways we hypothesized would complement one another in promoting an...

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Detalles Bibliográficos
Autores principales: Kim, Dae-Sun, Dastidar, Himika, Zhang, Chunfen, Zemp, Franz J., Lau, Keith, Ernst, Matthias, Rakic, Andrea, Sikdar, Saif, Rajwani, Jahanara, Naumenko, Victor, Balce, Dale R., Ewanchuk, Ben W., Tailor, Pankaj, Yates, Robin M., Jenne, Craig, Gafuik, Chris, Mahoney, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570934/
https://www.ncbi.nlm.nih.gov/pubmed/28839138
http://dx.doi.org/10.1038/s41467-017-00324-x

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