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Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study
Retinal microvascular changes indicating microvascular dysfunction have been shown to be associated with chronic kidney disease (CKD) in cross-sectional studies, but findings were mixed in prospective studies. We aimed to evaluate the relationship between retinal microvascular parameters and inciden...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570935/ https://www.ncbi.nlm.nih.gov/pubmed/28839244 http://dx.doi.org/10.1038/s41598-017-09204-2 |
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author | Yip, Wanfen Ong, Peng Guan Teo, Boon Wee Cheung, Carol Yim-lui Tai, E Shyong Cheng, Ching-Yu Lamoureux, Ecosse Wong, Tien Yin Sabanayagam, Charumathi |
author_facet | Yip, Wanfen Ong, Peng Guan Teo, Boon Wee Cheung, Carol Yim-lui Tai, E Shyong Cheng, Ching-Yu Lamoureux, Ecosse Wong, Tien Yin Sabanayagam, Charumathi |
author_sort | Yip, Wanfen |
collection | PubMed |
description | Retinal microvascular changes indicating microvascular dysfunction have been shown to be associated with chronic kidney disease (CKD) in cross-sectional studies, but findings were mixed in prospective studies. We aimed to evaluate the relationship between retinal microvascular parameters and incident CKD in an Asian population. We examined 1256 Malay adults aged 40–80 years from the Singapore Malay Eye Study, who attended both the baseline (2004–07) and the follow-up (2011–13) examinations and were free of prevalent CKD. We measured quantitative retinal vascular parameters (arteriolar and venular calibre, tortuosity, fractal dimension and branching angle) using a computer-assisted program (Singapore I Vessel Assessment, SIVA) and retinopathy (qualitative parameter) using the modified Airlie house classification system from baseline retinal photographs. Incident CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m(2) + 25% decrease in eGFR during follow-up. Over a median follow-up period of 6 years, 78 (6.21%) developed CKD (70.5% had diabetes). In multivariable models, smaller retinal arterioles (hazards ratio [95% confidence interval] = 1.34 [1.00–1.78]), larger retinal venules (2.35 [1.12–5.94] and presence of retinopathy (2.54 [1.48–4.36]) were associated with incident CKD. Our findings suggest that retinal microvascular abnormalities may reflect subclinical renal microvascular abnormalities involved in the development of CKD. |
format | Online Article Text |
id | pubmed-5570935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55709352017-09-01 Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study Yip, Wanfen Ong, Peng Guan Teo, Boon Wee Cheung, Carol Yim-lui Tai, E Shyong Cheng, Ching-Yu Lamoureux, Ecosse Wong, Tien Yin Sabanayagam, Charumathi Sci Rep Article Retinal microvascular changes indicating microvascular dysfunction have been shown to be associated with chronic kidney disease (CKD) in cross-sectional studies, but findings were mixed in prospective studies. We aimed to evaluate the relationship between retinal microvascular parameters and incident CKD in an Asian population. We examined 1256 Malay adults aged 40–80 years from the Singapore Malay Eye Study, who attended both the baseline (2004–07) and the follow-up (2011–13) examinations and were free of prevalent CKD. We measured quantitative retinal vascular parameters (arteriolar and venular calibre, tortuosity, fractal dimension and branching angle) using a computer-assisted program (Singapore I Vessel Assessment, SIVA) and retinopathy (qualitative parameter) using the modified Airlie house classification system from baseline retinal photographs. Incident CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m(2) + 25% decrease in eGFR during follow-up. Over a median follow-up period of 6 years, 78 (6.21%) developed CKD (70.5% had diabetes). In multivariable models, smaller retinal arterioles (hazards ratio [95% confidence interval] = 1.34 [1.00–1.78]), larger retinal venules (2.35 [1.12–5.94] and presence of retinopathy (2.54 [1.48–4.36]) were associated with incident CKD. Our findings suggest that retinal microvascular abnormalities may reflect subclinical renal microvascular abnormalities involved in the development of CKD. Nature Publishing Group UK 2017-08-24 /pmc/articles/PMC5570935/ /pubmed/28839244 http://dx.doi.org/10.1038/s41598-017-09204-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yip, Wanfen Ong, Peng Guan Teo, Boon Wee Cheung, Carol Yim-lui Tai, E Shyong Cheng, Ching-Yu Lamoureux, Ecosse Wong, Tien Yin Sabanayagam, Charumathi Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title | Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title_full | Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title_fullStr | Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title_full_unstemmed | Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title_short | Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study |
title_sort | retinal vascular imaging markers and incident chronic kidney disease: a prospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570935/ https://www.ncbi.nlm.nih.gov/pubmed/28839244 http://dx.doi.org/10.1038/s41598-017-09204-2 |
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