Are We Approaching a Speed Limit for the Chromatographic Separation of Enantiomers?

[Image: see text] As the speed of chromatographic enantioseparations advances to the point where the enantiomers of most chiral compounds can be resolved in less than a minute, some in less than a second, we pose the question of how this field is likely to develop over the next few years. Are we approaching a fundamental speed limit, or will further technological advances continue to deliver faster and faster separations? Are faster separations even needed for chemical research, and if so, how will they help? We herein examine this trend, investigating the barriers that currently limit speed and offering some insights into the continued evolution of fast chromatographic enantioseparations.