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Neutrophil dysregulation during sepsis: an overview and update
Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571534/ https://www.ncbi.nlm.nih.gov/pubmed/28244690 http://dx.doi.org/10.1111/jcmm.13112 |
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author | Shen, Xiao‐Fei Cao, Ke Jiang, Jin‐peng Guan, Wen‐Xian Du, Jun‐Feng |
author_facet | Shen, Xiao‐Fei Cao, Ke Jiang, Jin‐peng Guan, Wen‐Xian Du, Jun‐Feng |
author_sort | Shen, Xiao‐Fei |
collection | PubMed |
description | Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis. |
format | Online Article Text |
id | pubmed-5571534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55715342017-09-01 Neutrophil dysregulation during sepsis: an overview and update Shen, Xiao‐Fei Cao, Ke Jiang, Jin‐peng Guan, Wen‐Xian Du, Jun‐Feng J Cell Mol Med Reviews Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis. John Wiley and Sons Inc. 2017-02-28 2017-09 /pmc/articles/PMC5571534/ /pubmed/28244690 http://dx.doi.org/10.1111/jcmm.13112 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Shen, Xiao‐Fei Cao, Ke Jiang, Jin‐peng Guan, Wen‐Xian Du, Jun‐Feng Neutrophil dysregulation during sepsis: an overview and update |
title | Neutrophil dysregulation during sepsis: an overview and update |
title_full | Neutrophil dysregulation during sepsis: an overview and update |
title_fullStr | Neutrophil dysregulation during sepsis: an overview and update |
title_full_unstemmed | Neutrophil dysregulation during sepsis: an overview and update |
title_short | Neutrophil dysregulation during sepsis: an overview and update |
title_sort | neutrophil dysregulation during sepsis: an overview and update |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571534/ https://www.ncbi.nlm.nih.gov/pubmed/28244690 http://dx.doi.org/10.1111/jcmm.13112 |
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