Identifying pleiotropic genes in genome-wide association studies from related subjects using the linear mixed model and Fisher combination function

BACKGROUND: A multivariate genome-wide association test is proposed for analyzing data on multivariate quantitative phenotypes collected from related subjects. The proposed method is a two-step approach. The first step models the association between the genotype and marginal phenotype using a linear...

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Detalles Bibliográficos
Autores principales: Yang, James J., Williams, L Keoki, Buu, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571642/
https://www.ncbi.nlm.nih.gov/pubmed/28836938
http://dx.doi.org/10.1186/s12859-017-1791-9

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