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Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening

This study sought to identify factors related to the prognosis of intra-abdominal liposarcoma and to determine the optimal minimum duration for remnant tumor screening. Intra-abdominal liposarcoma is associated with high rates of incomplete resection and recurrence requiring a sophisticated follow-u...

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Autores principales: Rhu, Jinsoo, Cho, Chan Woo, Lee, Kyo Won, Park, Hyojun, Park, Jae Berm, Choi, Yoon-La, Kim, Sung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571678/
https://www.ncbi.nlm.nih.gov/pubmed/28816941
http://dx.doi.org/10.1097/MD.0000000000007537
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author Rhu, Jinsoo
Cho, Chan Woo
Lee, Kyo Won
Park, Hyojun
Park, Jae Berm
Choi, Yoon-La
Kim, Sung Joo
author_facet Rhu, Jinsoo
Cho, Chan Woo
Lee, Kyo Won
Park, Hyojun
Park, Jae Berm
Choi, Yoon-La
Kim, Sung Joo
author_sort Rhu, Jinsoo
collection PubMed
description This study sought to identify factors related to the prognosis of intra-abdominal liposarcoma and to determine the optimal minimum duration for remnant tumor screening. Intra-abdominal liposarcoma is associated with high rates of incomplete resection and recurrence requiring a sophisticated follow-up strategy. Patients who underwent surgery for intra-abdominal liposarcoma were included. Cox analyses were used to analyze factors related to recurrence and survival. To determine the optimal minimum duration for remnant tumor screening, patients with recurrence after surgery despite gross complete resection were grouped by a postoperative detection time of 1, 3, or 6 months. Their survivals were compared to the gross incomplete resection group. A total of 168 patients were included. Kaplan–Meier 5-year disease-free survival was 35.9% and overall survival was 66.5%. Multiplicity (HR=2.528, CI=1.585–4.033, P < .001), organ invasion (HR = 1.628, CI = 1.020–2.598, P = .041), and FNCLCC grades (G2,HR = 1.730, CI = 1.000–2.994; G3, HR = 3.812, CI = 2.112–6.880, P < .001) were related to recurrence. Multiplicity (HR = 2.131, CI = 1.050–4.329, P = .036), organ resection ≥3 (HR = 2.857, CI = 1.322–6.174, P = .008), gross incomplete resection (HR = 4.368, CI = 1.890–10.097, P = .001), positive margin (HR = 2.766, CI = 1.367–5.600, P = .005), FNCLCC grade (G2,HR = 2.044, CI = 0.937–4.459; G3,HR = 4.470, CI = 1.893–10.557; P = .003), and RT (HR = 0.322, CI = 0.160–0.648, P = .001) were related to overall survival. Dividing patients into 1 month (P = .097) and 3 months (P = 0.063) did not yield significant differences in univariate analyses, whereas 6 months showed significant difference (P = .015) compared to the gross incomplete resection group. Patients with tumors detected within 6 months showed similar survival to the gross incomplete resection group (HR = 0.552, CI = 0.241–1.260, P = .158), whereas patients with tumor detection after 6 months showed better survival (HR = 0.325, CI = 0.149–0.708, P = .005). In conclusion, minimum duration of 6 months for remnant tumor screening using CT seems optimal.
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spelling pubmed-55716782017-09-07 Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening Rhu, Jinsoo Cho, Chan Woo Lee, Kyo Won Park, Hyojun Park, Jae Berm Choi, Yoon-La Kim, Sung Joo Medicine (Baltimore) 5700 This study sought to identify factors related to the prognosis of intra-abdominal liposarcoma and to determine the optimal minimum duration for remnant tumor screening. Intra-abdominal liposarcoma is associated with high rates of incomplete resection and recurrence requiring a sophisticated follow-up strategy. Patients who underwent surgery for intra-abdominal liposarcoma were included. Cox analyses were used to analyze factors related to recurrence and survival. To determine the optimal minimum duration for remnant tumor screening, patients with recurrence after surgery despite gross complete resection were grouped by a postoperative detection time of 1, 3, or 6 months. Their survivals were compared to the gross incomplete resection group. A total of 168 patients were included. Kaplan–Meier 5-year disease-free survival was 35.9% and overall survival was 66.5%. Multiplicity (HR=2.528, CI=1.585–4.033, P < .001), organ invasion (HR = 1.628, CI = 1.020–2.598, P = .041), and FNCLCC grades (G2,HR = 1.730, CI = 1.000–2.994; G3, HR = 3.812, CI = 2.112–6.880, P < .001) were related to recurrence. Multiplicity (HR = 2.131, CI = 1.050–4.329, P = .036), organ resection ≥3 (HR = 2.857, CI = 1.322–6.174, P = .008), gross incomplete resection (HR = 4.368, CI = 1.890–10.097, P = .001), positive margin (HR = 2.766, CI = 1.367–5.600, P = .005), FNCLCC grade (G2,HR = 2.044, CI = 0.937–4.459; G3,HR = 4.470, CI = 1.893–10.557; P = .003), and RT (HR = 0.322, CI = 0.160–0.648, P = .001) were related to overall survival. Dividing patients into 1 month (P = .097) and 3 months (P = 0.063) did not yield significant differences in univariate analyses, whereas 6 months showed significant difference (P = .015) compared to the gross incomplete resection group. Patients with tumors detected within 6 months showed similar survival to the gross incomplete resection group (HR = 0.552, CI = 0.241–1.260, P = .158), whereas patients with tumor detection after 6 months showed better survival (HR = 0.325, CI = 0.149–0.708, P = .005). In conclusion, minimum duration of 6 months for remnant tumor screening using CT seems optimal. Wolters Kluwer Health 2017-08-18 /pmc/articles/PMC5571678/ /pubmed/28816941 http://dx.doi.org/10.1097/MD.0000000000007537 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5700
Rhu, Jinsoo
Cho, Chan Woo
Lee, Kyo Won
Park, Hyojun
Park, Jae Berm
Choi, Yoon-La
Kim, Sung Joo
Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title_full Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title_fullStr Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title_full_unstemmed Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title_short Single-center experience with intra-abdominal liposarcoma: Optimal minimum duration for postoperative remnant tumor screening
title_sort single-center experience with intra-abdominal liposarcoma: optimal minimum duration for postoperative remnant tumor screening
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571678/
https://www.ncbi.nlm.nih.gov/pubmed/28816941
http://dx.doi.org/10.1097/MD.0000000000007537
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