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Effective apatinib treatment of pleomorphic liposarcoma: A case report

RATIONALE: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. PATIENT CONCERNS: We presented an 81-year-old Chinese woman with advanced PLS who received apatin...

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Autores principales: Yan, Peng, Sun, Mei-Li, Sun, Yu-Ping, Liu, Chuan-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571695/
https://www.ncbi.nlm.nih.gov/pubmed/28816958
http://dx.doi.org/10.1097/MD.0000000000007771
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author Yan, Peng
Sun, Mei-Li
Sun, Yu-Ping
Liu, Chuan-Yong
author_facet Yan, Peng
Sun, Mei-Li
Sun, Yu-Ping
Liu, Chuan-Yong
author_sort Yan, Peng
collection PubMed
description RATIONALE: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. PATIENT CONCERNS: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy. DIAGNOSES: The patient was diagnosed as having PLS by biopsy. Interventions: After a failed chemotherapy, apatinib started to be taken orally 425 mg per day. OUTCOMES: This patient achieved 3-month progression-free survival (PFS) and a higher quality of life. Meanwhile, this patient suffered grade 2 hypertension and grade 3 hand–foot syndrome (HFS). Lessons: In this case, apatinib presented good efficacy and safety to treat PLS. Randomized clinical studies are required to confirm the efficacy and safety of apatinib in the treatment of PLS.
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spelling pubmed-55716952017-09-07 Effective apatinib treatment of pleomorphic liposarcoma: A case report Yan, Peng Sun, Mei-Li Sun, Yu-Ping Liu, Chuan-Yong Medicine (Baltimore) 5700 RATIONALE: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. PATIENT CONCERNS: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy. DIAGNOSES: The patient was diagnosed as having PLS by biopsy. Interventions: After a failed chemotherapy, apatinib started to be taken orally 425 mg per day. OUTCOMES: This patient achieved 3-month progression-free survival (PFS) and a higher quality of life. Meanwhile, this patient suffered grade 2 hypertension and grade 3 hand–foot syndrome (HFS). Lessons: In this case, apatinib presented good efficacy and safety to treat PLS. Randomized clinical studies are required to confirm the efficacy and safety of apatinib in the treatment of PLS. Wolters Kluwer Health 2017-08-18 /pmc/articles/PMC5571695/ /pubmed/28816958 http://dx.doi.org/10.1097/MD.0000000000007771 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5700
Yan, Peng
Sun, Mei-Li
Sun, Yu-Ping
Liu, Chuan-Yong
Effective apatinib treatment of pleomorphic liposarcoma: A case report
title Effective apatinib treatment of pleomorphic liposarcoma: A case report
title_full Effective apatinib treatment of pleomorphic liposarcoma: A case report
title_fullStr Effective apatinib treatment of pleomorphic liposarcoma: A case report
title_full_unstemmed Effective apatinib treatment of pleomorphic liposarcoma: A case report
title_short Effective apatinib treatment of pleomorphic liposarcoma: A case report
title_sort effective apatinib treatment of pleomorphic liposarcoma: a case report
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571695/
https://www.ncbi.nlm.nih.gov/pubmed/28816958
http://dx.doi.org/10.1097/MD.0000000000007771
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