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Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article

The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities. Patients with RA diagnosis attending the rheumatology ou...

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Autores principales: Vázquez-Del Mercado, Mónica, Gomez-Bañuelos, Eduardo, Chavarria-Avila, Efrain, Cardona-Muñoz, Ernesto, Ramos-Becerra, Carlos, Alanis-Sanchez, Adrián, Cardona-Muller, David, Grover-Paez, Fernando, Perez-Vazquez, Felipe de J., Navarro-Hernandez, Rosa-Elena, Valadez-Soto, Jorge M., Saldaña-Millan, Adan A., Gonzalez-Rosas, Lorena, Ramos-Lopez, Gabriel, Petri, Marcelo H., Bäck, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571726/
https://www.ncbi.nlm.nih.gov/pubmed/28816989
http://dx.doi.org/10.1097/MD.0000000000007862
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author Vázquez-Del Mercado, Mónica
Gomez-Bañuelos, Eduardo
Chavarria-Avila, Efrain
Cardona-Muñoz, Ernesto
Ramos-Becerra, Carlos
Alanis-Sanchez, Adrián
Cardona-Muller, David
Grover-Paez, Fernando
Perez-Vazquez, Felipe de J.
Navarro-Hernandez, Rosa-Elena
Valadez-Soto, Jorge M.
Saldaña-Millan, Adan A.
Gonzalez-Rosas, Lorena
Ramos-Lopez, Gabriel
Petri, Marcelo H.
Bäck, Magnus
author_facet Vázquez-Del Mercado, Mónica
Gomez-Bañuelos, Eduardo
Chavarria-Avila, Efrain
Cardona-Muñoz, Ernesto
Ramos-Becerra, Carlos
Alanis-Sanchez, Adrián
Cardona-Muller, David
Grover-Paez, Fernando
Perez-Vazquez, Felipe de J.
Navarro-Hernandez, Rosa-Elena
Valadez-Soto, Jorge M.
Saldaña-Millan, Adan A.
Gonzalez-Rosas, Lorena
Ramos-Lopez, Gabriel
Petri, Marcelo H.
Bäck, Magnus
author_sort Vázquez-Del Mercado, Mónica
collection PubMed
description The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities. Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Arterial stiffness was measured as cfPWV by noninvasive tonometry. A multivariate regression model was used to analyze the contribution of RA disease duration and age on cfPWV. cfPWV was positively correlated with age (r = 0.450, P < .001), RA disease duration (r = 0.340, P < .001), total cholesterol (r = 0.312, P = .002), and low density lipoprotein (LDL-c) cholesterol (r = 0.268, P = .012). Patients with a RA disease duration ≥10 years exhibited significantly increased cfPWV compared with patients with disease duration <2 years (8.4 ± 1.8 vs 7.0 ± 0.8) and ≥2 to <10 years (8.4 ± 1.8 vs 7.8 ± 1.3), respectively. Age, RA disease duration, and triglycerides were predictors of cfPWV in multivariate analyses. According to the β-coefficients, each year of disease duration (β = 0.072) had a greater impact on cfPWV than age (β = 0.054). Each year of life with RA contributes to a higher rate of vascular aging or stiffening than a year of life without RA. The cumulative damage provided by RA was most pronounced in patients with disease duration ≥10 years.
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spelling pubmed-55717262017-09-07 Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article Vázquez-Del Mercado, Mónica Gomez-Bañuelos, Eduardo Chavarria-Avila, Efrain Cardona-Muñoz, Ernesto Ramos-Becerra, Carlos Alanis-Sanchez, Adrián Cardona-Muller, David Grover-Paez, Fernando Perez-Vazquez, Felipe de J. Navarro-Hernandez, Rosa-Elena Valadez-Soto, Jorge M. Saldaña-Millan, Adan A. Gonzalez-Rosas, Lorena Ramos-Lopez, Gabriel Petri, Marcelo H. Bäck, Magnus Medicine (Baltimore) 6900 The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities. Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Arterial stiffness was measured as cfPWV by noninvasive tonometry. A multivariate regression model was used to analyze the contribution of RA disease duration and age on cfPWV. cfPWV was positively correlated with age (r = 0.450, P < .001), RA disease duration (r = 0.340, P < .001), total cholesterol (r = 0.312, P = .002), and low density lipoprotein (LDL-c) cholesterol (r = 0.268, P = .012). Patients with a RA disease duration ≥10 years exhibited significantly increased cfPWV compared with patients with disease duration <2 years (8.4 ± 1.8 vs 7.0 ± 0.8) and ≥2 to <10 years (8.4 ± 1.8 vs 7.8 ± 1.3), respectively. Age, RA disease duration, and triglycerides were predictors of cfPWV in multivariate analyses. According to the β-coefficients, each year of disease duration (β = 0.072) had a greater impact on cfPWV than age (β = 0.054). Each year of life with RA contributes to a higher rate of vascular aging or stiffening than a year of life without RA. The cumulative damage provided by RA was most pronounced in patients with disease duration ≥10 years. Wolters Kluwer Health 2017-08-18 /pmc/articles/PMC5571726/ /pubmed/28816989 http://dx.doi.org/10.1097/MD.0000000000007862 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 6900
Vázquez-Del Mercado, Mónica
Gomez-Bañuelos, Eduardo
Chavarria-Avila, Efrain
Cardona-Muñoz, Ernesto
Ramos-Becerra, Carlos
Alanis-Sanchez, Adrián
Cardona-Muller, David
Grover-Paez, Fernando
Perez-Vazquez, Felipe de J.
Navarro-Hernandez, Rosa-Elena
Valadez-Soto, Jorge M.
Saldaña-Millan, Adan A.
Gonzalez-Rosas, Lorena
Ramos-Lopez, Gabriel
Petri, Marcelo H.
Bäck, Magnus
Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title_full Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title_fullStr Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title_full_unstemmed Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title_short Disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: A STROBE-compliant article
title_sort disease duration of rheumatoid arthritis is a predictor of vascular stiffness: a cross-sectional study in patients without known cardiovascular comorbidities: a strobe-compliant article
topic 6900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571726/
https://www.ncbi.nlm.nih.gov/pubmed/28816989
http://dx.doi.org/10.1097/MD.0000000000007862
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