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Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma

BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and...

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Autores principales: Ranhem, Cecilia, Lillsunde Larsson, Gabriella, Hedman, Håkan, Lindquist, David, Karlsson, Mats G., Hellström, Ann-Cathrin, Östensson, Ellinor, Sorbe, Bengt, Hellman, Kristina, Andersson, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/
https://www.ncbi.nlm.nih.gov/pubmed/28841699
http://dx.doi.org/10.1371/journal.pone.0183816
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author Ranhem, Cecilia
Lillsunde Larsson, Gabriella
Hedman, Håkan
Lindquist, David
Karlsson, Mats G.
Hellström, Ann-Cathrin
Östensson, Ellinor
Sorbe, Bengt
Hellman, Kristina
Andersson, Sonia
author_facet Ranhem, Cecilia
Lillsunde Larsson, Gabriella
Hedman, Håkan
Lindquist, David
Karlsson, Mats G.
Hellström, Ann-Cathrin
Östensson, Ellinor
Sorbe, Bengt
Hellman, Kristina
Andersson, Sonia
author_sort Ranhem, Cecilia
collection PubMed
description BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients. METHODS: We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses. RESULTS: The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival. CONCLUSION: LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.
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spelling pubmed-55719122017-09-09 Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G. Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia PLoS One Research Article BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients. METHODS: We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses. RESULTS: The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival. CONCLUSION: LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified. Public Library of Science 2017-08-25 /pmc/articles/PMC5571912/ /pubmed/28841699 http://dx.doi.org/10.1371/journal.pone.0183816 Text en © 2017 Ranhem et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ranhem, Cecilia
Lillsunde Larsson, Gabriella
Hedman, Håkan
Lindquist, David
Karlsson, Mats G.
Hellström, Ann-Cathrin
Östensson, Ellinor
Sorbe, Bengt
Hellman, Kristina
Andersson, Sonia
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title_full Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title_fullStr Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title_full_unstemmed Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title_short Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
title_sort expression of lrig proteins as possible prognostic factors in primary vaginal carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/
https://www.ncbi.nlm.nih.gov/pubmed/28841699
http://dx.doi.org/10.1371/journal.pone.0183816
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