Cargando…
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/ https://www.ncbi.nlm.nih.gov/pubmed/28841699 http://dx.doi.org/10.1371/journal.pone.0183816 |
_version_ | 1783259428372348928 |
---|---|
author | Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G. Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia |
author_facet | Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G. Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia |
author_sort | Ranhem, Cecilia |
collection | PubMed |
description | BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients. METHODS: We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses. RESULTS: The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival. CONCLUSION: LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified. |
format | Online Article Text |
id | pubmed-5571912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55719122017-09-09 Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G. Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia PLoS One Research Article BACKGROUND: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients. METHODS: We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses. RESULTS: The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival. CONCLUSION: LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified. Public Library of Science 2017-08-25 /pmc/articles/PMC5571912/ /pubmed/28841699 http://dx.doi.org/10.1371/journal.pone.0183816 Text en © 2017 Ranhem et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ranhem, Cecilia Lillsunde Larsson, Gabriella Hedman, Håkan Lindquist, David Karlsson, Mats G. Hellström, Ann-Cathrin Östensson, Ellinor Sorbe, Bengt Hellman, Kristina Andersson, Sonia Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title_full | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title_fullStr | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title_full_unstemmed | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title_short | Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma |
title_sort | expression of lrig proteins as possible prognostic factors in primary vaginal carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571912/ https://www.ncbi.nlm.nih.gov/pubmed/28841699 http://dx.doi.org/10.1371/journal.pone.0183816 |
work_keys_str_mv | AT ranhemcecilia expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT lillsundelarssongabriella expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT hedmanhakan expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT lindquistdavid expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT karlssonmatsg expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT hellstromanncathrin expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT ostenssonellinor expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT sorbebengt expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT hellmankristina expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma AT anderssonsonia expressionoflrigproteinsaspossibleprognosticfactorsinprimaryvaginalcarcinoma |