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Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis

BACKGROUND: Ki67 is a good marker of cell proliferation in a variety of tumors. High ki67 levels are usually associated with poor prognosis. However, the relationship between Ki67 expression and the risk of malignancy of gastrointestinal stromal tumors (GISTs) is still poorly defined. The current me...

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Autores principales: Zhou, Yu, Hu, Wenqing, Chen, Ping, Abe, Masanobu, Shi, Lei, Tan, Si-yuan, Li, Yong, Zong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572037/
https://www.ncbi.nlm.nih.gov/pubmed/28834915
http://dx.doi.org/10.1097/MD.0000000000007911
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author Zhou, Yu
Hu, Wenqing
Chen, Ping
Abe, Masanobu
Shi, Lei
Tan, Si-yuan
Li, Yong
Zong, Liang
author_facet Zhou, Yu
Hu, Wenqing
Chen, Ping
Abe, Masanobu
Shi, Lei
Tan, Si-yuan
Li, Yong
Zong, Liang
author_sort Zhou, Yu
collection PubMed
description BACKGROUND: Ki67 is a good marker of cell proliferation in a variety of tumors. High ki67 levels are usually associated with poor prognosis. However, the relationship between Ki67 expression and the risk of malignancy of gastrointestinal stromal tumors (GISTs) is still poorly defined. The current meta-analysis was initiated to address this issue. METHODS: Studies reporting Ki67 expression and the risk of malignancy in GIST were found by searching Cochrane Library, PubMed, Medline, and Embase until October 31, 2016. A total of 9 studies involving 982 patients were included. Pooled odds ratio (OR) estimates and 95% confidence intervals (CIs) were calculated using a fixed-effect model. RESULTS: Meta-analysis showed no significant difference in the incidence of Ki67 overexpression between the very low NIH group and the low NIH group (OR: 0.66, 95% CI: 0.25–1.76; P = .41, P(heterogeneity) = .25). However, the incidence of Ki67 overexpression gradually increased from the low NIH group to the high NIH group (OR: 0.46, 95% CI: 0.27–0.80; P = .005, P(heterogeneity) = .13) and (OR: 0.22, 95% CI: 0.15–0.34; P < .00001, P(heterogeneity) = .33). CONCLUSIONS: There were more GIST patients with Ki67 overexpression in the intermediate and high NIH groups than in the low NIH group. Ki67 overexpression may be a useful marker of the risk of malignant GIST transformation.
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spelling pubmed-55720372017-09-06 Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis Zhou, Yu Hu, Wenqing Chen, Ping Abe, Masanobu Shi, Lei Tan, Si-yuan Li, Yong Zong, Liang Medicine (Baltimore) 4500 BACKGROUND: Ki67 is a good marker of cell proliferation in a variety of tumors. High ki67 levels are usually associated with poor prognosis. However, the relationship between Ki67 expression and the risk of malignancy of gastrointestinal stromal tumors (GISTs) is still poorly defined. The current meta-analysis was initiated to address this issue. METHODS: Studies reporting Ki67 expression and the risk of malignancy in GIST were found by searching Cochrane Library, PubMed, Medline, and Embase until October 31, 2016. A total of 9 studies involving 982 patients were included. Pooled odds ratio (OR) estimates and 95% confidence intervals (CIs) were calculated using a fixed-effect model. RESULTS: Meta-analysis showed no significant difference in the incidence of Ki67 overexpression between the very low NIH group and the low NIH group (OR: 0.66, 95% CI: 0.25–1.76; P = .41, P(heterogeneity) = .25). However, the incidence of Ki67 overexpression gradually increased from the low NIH group to the high NIH group (OR: 0.46, 95% CI: 0.27–0.80; P = .005, P(heterogeneity) = .13) and (OR: 0.22, 95% CI: 0.15–0.34; P < .00001, P(heterogeneity) = .33). CONCLUSIONS: There were more GIST patients with Ki67 overexpression in the intermediate and high NIH groups than in the low NIH group. Ki67 overexpression may be a useful marker of the risk of malignant GIST transformation. Wolters Kluwer Health 2017-08-25 /pmc/articles/PMC5572037/ /pubmed/28834915 http://dx.doi.org/10.1097/MD.0000000000007911 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Zhou, Yu
Hu, Wenqing
Chen, Ping
Abe, Masanobu
Shi, Lei
Tan, Si-yuan
Li, Yong
Zong, Liang
Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title_full Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title_fullStr Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title_full_unstemmed Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title_short Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis
title_sort ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: a systematic review and meta-analysis
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572037/
https://www.ncbi.nlm.nih.gov/pubmed/28834915
http://dx.doi.org/10.1097/MD.0000000000007911
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