Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Dev...

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Autores principales: Ribba, B, Grimm, HP, Agoram, B, Davies, MR, Gadkar, K, Niederer, S, van Riel, N, Timmis, J, van der Graaf, PH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572127/
https://www.ncbi.nlm.nih.gov/pubmed/28585415
http://dx.doi.org/10.1002/psp4.12206
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author Ribba, B
Grimm, HP
Agoram, B
Davies, MR
Gadkar, K
Niederer, S
van Riel, N
Timmis, J
van der Graaf, PH
author_facet Ribba, B
Grimm, HP
Agoram, B
Davies, MR
Gadkar, K
Niederer, S
van Riel, N
Timmis, J
van der Graaf, PH
author_sort Ribba, B
collection PubMed
description With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.
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spelling pubmed-55721272017-08-30 Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation Ribba, B Grimm, HP Agoram, B Davies, MR Gadkar, K Niederer, S van Riel, N Timmis, J van der Graaf, PH CPT Pharmacometrics Syst Pharmacol Perspectives With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions. John Wiley and Sons Inc. 2017-07-11 2017-08 /pmc/articles/PMC5572127/ /pubmed/28585415 http://dx.doi.org/10.1002/psp4.12206 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspectives
Ribba, B
Grimm, HP
Agoram, B
Davies, MR
Gadkar, K
Niederer, S
van Riel, N
Timmis, J
van der Graaf, PH
Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title_full Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title_fullStr Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title_full_unstemmed Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title_short Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation
title_sort methodologies for quantitative systems pharmacology (qsp) models: design and estimation
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572127/
https://www.ncbi.nlm.nih.gov/pubmed/28585415
http://dx.doi.org/10.1002/psp4.12206
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