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Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants

BACKGROUND: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors,...

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Autores principales: Pour, Mahdi Alikhani, Sardari, Soroush, Eslamifar, Ali, Azhar, Abid, Rezvani, Mohammad, Nazari, Milad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572436/
https://www.ncbi.nlm.nih.gov/pubmed/28454485
http://dx.doi.org/10.18869/acadpub.ibj.21.6.400
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author Pour, Mahdi Alikhani
Sardari, Soroush
Eslamifar, Ali
Azhar, Abid
Rezvani, Mohammad
Nazari, Milad
author_facet Pour, Mahdi Alikhani
Sardari, Soroush
Eslamifar, Ali
Azhar, Abid
Rezvani, Mohammad
Nazari, Milad
author_sort Pour, Mahdi Alikhani
collection PubMed
description BACKGROUND: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. METHODS: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists. Next, the fast and cost-effective cheminformatics methods incorporated in PubChem were applied to detect some compounds similar to reported anticoagulants. Subsequently, 15 native medical plants of Iran containing the potential anticoagulants were selected. The selected plants were purchased and chopped, and the potential compounds were extracted by ethanol. Then three concentrations of extracts (1, 10, and 100 µg per ml) were made. Finally, anticoagulant effect of the selected plants was evaluated by in vitro prothrombin time and activated partial thromboplastin time coagulation tests. RESULTS: Among the 15 selected medicinal plants, three plants, including Terminalia bellirica (P=0.0019), Astragalus arbusculinus (P=0.0021), and Origanum vulgare (P=0.0014) showed a more promising anticoagulant effect in comparison to the control. CONCLUSION: The anticoagulant activity was identified for the first time in these three plants. Further in vivo study and mechanism of action assay are required to be performed on these three plants, which could be suitable candidates for use as natural anticoagulant medicines.
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spelling pubmed-55724362017-11-01 Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants Pour, Mahdi Alikhani Sardari, Soroush Eslamifar, Ali Azhar, Abid Rezvani, Mohammad Nazari, Milad Iran Biomed J Full Length BACKGROUND: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. METHODS: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists. Next, the fast and cost-effective cheminformatics methods incorporated in PubChem were applied to detect some compounds similar to reported anticoagulants. Subsequently, 15 native medical plants of Iran containing the potential anticoagulants were selected. The selected plants were purchased and chopped, and the potential compounds were extracted by ethanol. Then three concentrations of extracts (1, 10, and 100 µg per ml) were made. Finally, anticoagulant effect of the selected plants was evaluated by in vitro prothrombin time and activated partial thromboplastin time coagulation tests. RESULTS: Among the 15 selected medicinal plants, three plants, including Terminalia bellirica (P=0.0019), Astragalus arbusculinus (P=0.0021), and Origanum vulgare (P=0.0014) showed a more promising anticoagulant effect in comparison to the control. CONCLUSION: The anticoagulant activity was identified for the first time in these three plants. Further in vivo study and mechanism of action assay are required to be performed on these three plants, which could be suitable candidates for use as natural anticoagulant medicines. Pasteur Institute 2017-11 /pmc/articles/PMC5572436/ /pubmed/28454485 http://dx.doi.org/10.18869/acadpub.ibj.21.6.400 Text en Copyright: © Iranian Biomedical Journal http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length
Pour, Mahdi Alikhani
Sardari, Soroush
Eslamifar, Ali
Azhar, Abid
Rezvani, Mohammad
Nazari, Milad
Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title_full Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title_fullStr Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title_full_unstemmed Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title_short Cheminformatics-Based Anticoagulant Study of Traditionally Used Medicinal Plants
title_sort cheminformatics-based anticoagulant study of traditionally used medicinal plants
topic Full Length
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572436/
https://www.ncbi.nlm.nih.gov/pubmed/28454485
http://dx.doi.org/10.18869/acadpub.ibj.21.6.400
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