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HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells

B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradati...

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Detalles Bibliográficos
Autores principales: Wang, Wen-Fang, Yan, Li, Liu, Zhao, Liu, Lan-Xuan, Lin, Jian, Liu, Zhi-Yin, Chen, Xiong-Ping, Zhang, Wu, Xu, Zi-Zhen, Shi, Ting, Li, Jun-Min, Zhao, Yi-Lei, Meng, Guoyu, Xia, Yi, Li, Jian-Yong, Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572455/
https://www.ncbi.nlm.nih.gov/pubmed/28842558
http://dx.doi.org/10.1038/s41467-017-00476-w