An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of infl...

Descripción completa

Detalles Bibliográficos
Autores principales: Tirinato, L., Pagliari, F., Limongi, T., Marini, M., Falqui, A., Seco, J., Candeloro, P., Liberale, C., Di Fabrizio, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572636/
https://www.ncbi.nlm.nih.gov/pubmed/28883835
http://dx.doi.org/10.1155/2017/1656053
_version_ 1783259555061301248
author Tirinato, L.
Pagliari, F.
Limongi, T.
Marini, M.
Falqui, A.
Seco, J.
Candeloro, P.
Liberale, C.
Di Fabrizio, E.
author_facet Tirinato, L.
Pagliari, F.
Limongi, T.
Marini, M.
Falqui, A.
Seco, J.
Candeloro, P.
Liberale, C.
Di Fabrizio, E.
author_sort Tirinato, L.
collection PubMed
description For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
format Online
Article
Text
id pubmed-5572636
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-55726362017-09-07 An Overview of Lipid Droplets in Cancer and Cancer Stem Cells Tirinato, L. Pagliari, F. Limongi, T. Marini, M. Falqui, A. Seco, J. Candeloro, P. Liberale, C. Di Fabrizio, E. Stem Cells Int Review Article For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes. Hindawi 2017 2017-08-13 /pmc/articles/PMC5572636/ /pubmed/28883835 http://dx.doi.org/10.1155/2017/1656053 Text en Copyright © 2017 L. Tirinato et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tirinato, L.
Pagliari, F.
Limongi, T.
Marini, M.
Falqui, A.
Seco, J.
Candeloro, P.
Liberale, C.
Di Fabrizio, E.
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title_full An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title_fullStr An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title_full_unstemmed An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title_short An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
title_sort overview of lipid droplets in cancer and cancer stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572636/
https://www.ncbi.nlm.nih.gov/pubmed/28883835
http://dx.doi.org/10.1155/2017/1656053
work_keys_str_mv AT tirinatol anoverviewoflipiddropletsincancerandcancerstemcells
AT pagliarif anoverviewoflipiddropletsincancerandcancerstemcells
AT limongit anoverviewoflipiddropletsincancerandcancerstemcells
AT marinim anoverviewoflipiddropletsincancerandcancerstemcells
AT falquia anoverviewoflipiddropletsincancerandcancerstemcells
AT secoj anoverviewoflipiddropletsincancerandcancerstemcells
AT candelorop anoverviewoflipiddropletsincancerandcancerstemcells
AT liberalec anoverviewoflipiddropletsincancerandcancerstemcells
AT difabrizioe anoverviewoflipiddropletsincancerandcancerstemcells
AT tirinatol overviewoflipiddropletsincancerandcancerstemcells
AT pagliarif overviewoflipiddropletsincancerandcancerstemcells
AT limongit overviewoflipiddropletsincancerandcancerstemcells
AT marinim overviewoflipiddropletsincancerandcancerstemcells
AT falquia overviewoflipiddropletsincancerandcancerstemcells
AT secoj overviewoflipiddropletsincancerandcancerstemcells
AT candelorop overviewoflipiddropletsincancerandcancerstemcells
AT liberalec overviewoflipiddropletsincancerandcancerstemcells
AT difabrizioe overviewoflipiddropletsincancerandcancerstemcells

Ejemplares similares