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In situ repair of bone and cartilage defects using 3D scanning and 3D printing

Three-dimensional (3D) printing is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. However, the use of robotic bioprinters alone is not sufficient for disease treatment. This study aimed to report the combined applicatio...

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Autores principales: Li, Lan, Yu, Fei, Shi, Jianping, Shen, Sheng, Teng, Huajian, Yang, Jiquan, Wang, Xingsong, Jiang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572706/
https://www.ncbi.nlm.nih.gov/pubmed/28842703
http://dx.doi.org/10.1038/s41598-017-10060-3
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author Li, Lan
Yu, Fei
Shi, Jianping
Shen, Sheng
Teng, Huajian
Yang, Jiquan
Wang, Xingsong
Jiang, Qing
author_facet Li, Lan
Yu, Fei
Shi, Jianping
Shen, Sheng
Teng, Huajian
Yang, Jiquan
Wang, Xingsong
Jiang, Qing
author_sort Li, Lan
collection PubMed
description Three-dimensional (3D) printing is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. However, the use of robotic bioprinters alone is not sufficient for disease treatment. This study aimed to report the combined application of 3D scanning and 3D printing for treating bone and cartilage defects. Three different kinds of defect models were created to mimic three orthopedic diseases: large segmental defects of long bones, free-form fracture of femoral condyle, and International Cartilage Repair Society grade IV chondral lesion. Feasibility of in situ 3D bioprinting for these diseases was explored. The 3D digital models of samples with defects and corresponding healthy parts were obtained using high-resolution 3D scanning. The Boolean operation was used to achieve the shape of the defects, and then the target geometries were imported in a 3D bioprinter. Two kinds of photopolymerized hydrogels were synthesized as bioinks. Finally, the defects of bone and cartilage were restored perfectly in situ using 3D bioprinting. The results of this study suggested that 3D scanning and 3D bioprinting could provide another strategy for tissue engineering and regenerative medicine.
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spelling pubmed-55727062017-09-01 In situ repair of bone and cartilage defects using 3D scanning and 3D printing Li, Lan Yu, Fei Shi, Jianping Shen, Sheng Teng, Huajian Yang, Jiquan Wang, Xingsong Jiang, Qing Sci Rep Article Three-dimensional (3D) printing is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. However, the use of robotic bioprinters alone is not sufficient for disease treatment. This study aimed to report the combined application of 3D scanning and 3D printing for treating bone and cartilage defects. Three different kinds of defect models were created to mimic three orthopedic diseases: large segmental defects of long bones, free-form fracture of femoral condyle, and International Cartilage Repair Society grade IV chondral lesion. Feasibility of in situ 3D bioprinting for these diseases was explored. The 3D digital models of samples with defects and corresponding healthy parts were obtained using high-resolution 3D scanning. The Boolean operation was used to achieve the shape of the defects, and then the target geometries were imported in a 3D bioprinter. Two kinds of photopolymerized hydrogels were synthesized as bioinks. Finally, the defects of bone and cartilage were restored perfectly in situ using 3D bioprinting. The results of this study suggested that 3D scanning and 3D bioprinting could provide another strategy for tissue engineering and regenerative medicine. Nature Publishing Group UK 2017-08-25 /pmc/articles/PMC5572706/ /pubmed/28842703 http://dx.doi.org/10.1038/s41598-017-10060-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Lan
Yu, Fei
Shi, Jianping
Shen, Sheng
Teng, Huajian
Yang, Jiquan
Wang, Xingsong
Jiang, Qing
In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title_full In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title_fullStr In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title_full_unstemmed In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title_short In situ repair of bone and cartilage defects using 3D scanning and 3D printing
title_sort in situ repair of bone and cartilage defects using 3d scanning and 3d printing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572706/
https://www.ncbi.nlm.nih.gov/pubmed/28842703
http://dx.doi.org/10.1038/s41598-017-10060-3
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