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Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP(2)-producing enzyme PIP5K1A

HGF and its receptor c-Met are critical molecules in various biological processes. Others and we have previously shown that the small GTPase Arf6 plays a pivotal role in HGF signaling in hepatocytes. However, the molecular mechanism of how Arf6 regulates HGF signaling is unclear. Here, we show that...

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Detalles Bibliográficos
Autores principales: Tsai, Meng-Tsz, Katagiri, Naohiro, Ohbayashi, Norihiko, Iwasaki, Kenichi, Ohkohchi, Nobuhiro, Ding, Shih-Torng, Kanaho, Yasunori, Funakoshi, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572707/
https://www.ncbi.nlm.nih.gov/pubmed/28842595
http://dx.doi.org/10.1038/s41598-017-09633-z