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No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum

Whether malaria parasites can manipulate mosquito host choice in ways that enhance parasite transmission toward suitable hosts and/or reduce mosquito attraction to unsuitable hosts (i.e. specific manipulation) is unknown. To address this question, we experimentally infected three species of mosquito...

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Autores principales: Nguyen, Phuong L., Vantaux, Amélie, Hien, Domonbabele FdS, Dabiré, Kounbobr R., Yameogo, Bienvenue K., Gouagna, Louis-Clément, Fontenille, Didier, Renaud, François, Simard, Frédéric, Costantini, Carlo, Thomas, Fréderic, Cohuet, Anna, Lefèvre, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572726/
https://www.ncbi.nlm.nih.gov/pubmed/28842622
http://dx.doi.org/10.1038/s41598-017-09821-x
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author Nguyen, Phuong L.
Vantaux, Amélie
Hien, Domonbabele FdS
Dabiré, Kounbobr R.
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Fontenille, Didier
Renaud, François
Simard, Frédéric
Costantini, Carlo
Thomas, Fréderic
Cohuet, Anna
Lefèvre, Thierry
author_facet Nguyen, Phuong L.
Vantaux, Amélie
Hien, Domonbabele FdS
Dabiré, Kounbobr R.
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Fontenille, Didier
Renaud, François
Simard, Frédéric
Costantini, Carlo
Thomas, Fréderic
Cohuet, Anna
Lefèvre, Thierry
author_sort Nguyen, Phuong L.
collection PubMed
description Whether malaria parasites can manipulate mosquito host choice in ways that enhance parasite transmission toward suitable hosts and/or reduce mosquito attraction to unsuitable hosts (i.e. specific manipulation) is unknown. To address this question, we experimentally infected three species of mosquito vectors with wild isolates of the human malaria parasite Plasmodium falciparum, and examined the effects of immature and mature infections on mosquito behavioural responses to combinations of calf odour, human odour and outdoor air using a dual-port olfactometer. Regardless of parasite developmental stage and mosquito species, P. falciparum infection did not alter mosquito activation rate or their choice for human odours. The overall expression pattern of host choice of all three mosquito species was consistent with a high degree of anthropophily, with infected and uninfected individuals showing higher attraction toward human odour over calf odour, human odour over outdoor air, and outdoor air over calf odour. Our results suggest that, in this system, the parasite may not be able to manipulate the early long-range behavioural steps involved in the mosquito host-feeding process. Future studies are required to test whether malaria parasites can modify their mosquito host choice at a shorter range to enhance transmission.
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spelling pubmed-55727262017-09-01 No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum Nguyen, Phuong L. Vantaux, Amélie Hien, Domonbabele FdS Dabiré, Kounbobr R. Yameogo, Bienvenue K. Gouagna, Louis-Clément Fontenille, Didier Renaud, François Simard, Frédéric Costantini, Carlo Thomas, Fréderic Cohuet, Anna Lefèvre, Thierry Sci Rep Article Whether malaria parasites can manipulate mosquito host choice in ways that enhance parasite transmission toward suitable hosts and/or reduce mosquito attraction to unsuitable hosts (i.e. specific manipulation) is unknown. To address this question, we experimentally infected three species of mosquito vectors with wild isolates of the human malaria parasite Plasmodium falciparum, and examined the effects of immature and mature infections on mosquito behavioural responses to combinations of calf odour, human odour and outdoor air using a dual-port olfactometer. Regardless of parasite developmental stage and mosquito species, P. falciparum infection did not alter mosquito activation rate or their choice for human odours. The overall expression pattern of host choice of all three mosquito species was consistent with a high degree of anthropophily, with infected and uninfected individuals showing higher attraction toward human odour over calf odour, human odour over outdoor air, and outdoor air over calf odour. Our results suggest that, in this system, the parasite may not be able to manipulate the early long-range behavioural steps involved in the mosquito host-feeding process. Future studies are required to test whether malaria parasites can modify their mosquito host choice at a shorter range to enhance transmission. Nature Publishing Group UK 2017-08-25 /pmc/articles/PMC5572726/ /pubmed/28842622 http://dx.doi.org/10.1038/s41598-017-09821-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nguyen, Phuong L.
Vantaux, Amélie
Hien, Domonbabele FdS
Dabiré, Kounbobr R.
Yameogo, Bienvenue K.
Gouagna, Louis-Clément
Fontenille, Didier
Renaud, François
Simard, Frédéric
Costantini, Carlo
Thomas, Fréderic
Cohuet, Anna
Lefèvre, Thierry
No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title_full No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title_fullStr No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title_full_unstemmed No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title_short No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum
title_sort no evidence for manipulation of anopheles gambiae, an. coluzzii and an. arabiensis host preference by plasmodium falciparum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572726/
https://www.ncbi.nlm.nih.gov/pubmed/28842622
http://dx.doi.org/10.1038/s41598-017-09821-x
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