Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion

Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95(+), into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic pote...

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Detalles Bibliográficos
Autores principales: Herbst, Allen, Velásquez, Camilo Duque, Triscott, Elizabeth, Aiken, Judd M., McKenzie, Debbie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572867/
https://www.ncbi.nlm.nih.gov/pubmed/28820384
http://dx.doi.org/10.3201/eid2309.161474
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author Herbst, Allen
Velásquez, Camilo Duque
Triscott, Elizabeth
Aiken, Judd M.
McKenzie, Debbie
author_facet Herbst, Allen
Velásquez, Camilo Duque
Triscott, Elizabeth
Aiken, Judd M.
McKenzie, Debbie
author_sort Herbst, Allen
collection PubMed
description Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95(+), into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains.
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spelling pubmed-55728672017-09-02 Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion Herbst, Allen Velásquez, Camilo Duque Triscott, Elizabeth Aiken, Judd M. McKenzie, Debbie Emerg Infect Dis Research Letter Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95(+), into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains. Centers for Disease Control and Prevention 2017-09 /pmc/articles/PMC5572867/ /pubmed/28820384 http://dx.doi.org/10.3201/eid2309.161474 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Herbst, Allen
Velásquez, Camilo Duque
Triscott, Elizabeth
Aiken, Judd M.
McKenzie, Debbie
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title_full Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title_fullStr Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title_full_unstemmed Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title_short Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
title_sort chronic wasting disease prion strain emergence and host range expansion
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572867/
https://www.ncbi.nlm.nih.gov/pubmed/28820384
http://dx.doi.org/10.3201/eid2309.161474
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