Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France

FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA-producing extended spectrum β-lactamase Escherichia coli have circulated in France since 2012, potentially reducing the efficacy...

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Autores principales: Benzerara, Yahia, Gallah, Salah, Hommeril, Baptiste, Genel, Nathalie, Decré, Dominique, Rottman, Martin, Arlet, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572872/
https://www.ncbi.nlm.nih.gov/pubmed/28820368
http://dx.doi.org/10.3201/eid2309.170560
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author Benzerara, Yahia
Gallah, Salah
Hommeril, Baptiste
Genel, Nathalie
Decré, Dominique
Rottman, Martin
Arlet, Guillaume
author_facet Benzerara, Yahia
Gallah, Salah
Hommeril, Baptiste
Genel, Nathalie
Decré, Dominique
Rottman, Martin
Arlet, Guillaume
author_sort Benzerara, Yahia
collection PubMed
description FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA-producing extended spectrum β-lactamase Escherichia coli have circulated in France since 2012, potentially reducing the efficacy of fosfomycin in treating infections with antimicrobial drug–resistant gram-negative bacilli.
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spelling pubmed-55728722017-09-02 Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France Benzerara, Yahia Gallah, Salah Hommeril, Baptiste Genel, Nathalie Decré, Dominique Rottman, Martin Arlet, Guillaume Emerg Infect Dis Dispatch FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA-producing extended spectrum β-lactamase Escherichia coli have circulated in France since 2012, potentially reducing the efficacy of fosfomycin in treating infections with antimicrobial drug–resistant gram-negative bacilli. Centers for Disease Control and Prevention 2017-09 /pmc/articles/PMC5572872/ /pubmed/28820368 http://dx.doi.org/10.3201/eid2309.170560 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Benzerara, Yahia
Gallah, Salah
Hommeril, Baptiste
Genel, Nathalie
Decré, Dominique
Rottman, Martin
Arlet, Guillaume
Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title_full Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title_fullStr Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title_full_unstemmed Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title_short Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France
title_sort emergence of plasmid-mediated fosfomycin-resistance genes among escherichia coli isolates, france
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572872/
https://www.ncbi.nlm.nih.gov/pubmed/28820368
http://dx.doi.org/10.3201/eid2309.170560
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