Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense

Sigma-1 receptor (Sig-1R) functions as a chaperon that interacts with multiple proteins and lipids and is implicated in neurodegenerative and psychiatric diseases. Here, we used Sig-1R KO mice to examine brain expression profiles of astrocytes and ubiquitinated proteins, which are both hallmarks of...

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Detalles Bibliográficos
Autores principales: Weng, Tzu-Yu, Hung, Denise T., Su, Tsung-Ping, Tsai, Shang-Yi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573104/
https://www.ncbi.nlm.nih.gov/pubmed/28883901
http://dx.doi.org/10.1155/2017/4582135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573104/
https://www.ncbi.nlm.nih.gov/pubmed/28883901
http://dx.doi.org/10.1155/2017/4582135

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