Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity

Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the disease severity is immensely variable even among patients with similar CFTR mutations due to the possible effect of ‘modifier genes’. To identify...

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Detalles Bibliográficos
Autores principales: Kormann, Michael S. D., Dewerth, Alexander, Eichner, Felizitas, Baskaran, Praveen, Hector, Andreas, Regamey, Nicolas, Hartl, Dominik, Handgretinger, Rupert, Antony, Justin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573219/
https://www.ncbi.nlm.nih.gov/pubmed/28846703
http://dx.doi.org/10.1371/journal.pone.0183526

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