DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression

The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells. DDX3 de...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Ju, Wang, Wei-Ting, Tsai, Tsung-Yuan, Li, Hao-Kang, Lee, Yan-Hwa Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573351/
https://www.ncbi.nlm.nih.gov/pubmed/28842590
http://dx.doi.org/10.1038/s41598-017-09779-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573351/
https://www.ncbi.nlm.nih.gov/pubmed/28842590
http://dx.doi.org/10.1038/s41598-017-09779-w

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