Correlation between human ether‐a‐go‐go‐related gene channel inhibition and action potential prolongation

BACKGROUND AND PURPOSE: Human ether‐a‐go‐go‐related gene (hERG; K(v)11.1) channel inhibition is a widely accepted predictor of cardiac arrhythmia. hERG channel inhibition alone is often insufficient to predict pro‐arrhythmic drug effects. This study used a library of dofetilide derivatives to invest...

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Detalles Bibliográficos
Autores principales: Saxena, P, Hortigon‐Vinagre, M P, Beyl, S, Baburin, I, Andranovits, S, Iqbal, S M, Costa, A, IJzerman, A P, Kügler, P, Timin, E, Smith, G L, Hering, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573420/
https://www.ncbi.nlm.nih.gov/pubmed/28681507
http://dx.doi.org/10.1111/bph.13942

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