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Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis
PURPOSE: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. MATERIALS AND M...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Istanbul University Faculty of Dentisty
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573490/ https://www.ncbi.nlm.nih.gov/pubmed/28955581 http://dx.doi.org/10.17096/jiufd.42354 |
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author | Turkoglu, Oya Emingul, Gulnur Eren, Gulnihal Atmaca, Harika Kutukculer, Necil Atilla, Gul |
author_facet | Turkoglu, Oya Emingul, Gulnur Eren, Gulnihal Atmaca, Harika Kutukculer, Necil Atilla, Gul |
author_sort | Turkoglu, Oya |
collection | PubMed |
description | PURPOSE: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. MATERIALS AND METHODS: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. RESULTS: No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p<0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL-37 levels neither in healthy nor in gingivitis groups. CONCLUSION: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged. |
format | Online Article Text |
id | pubmed-5573490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Istanbul University Faculty of Dentisty |
record_format | MEDLINE/PubMed |
spelling | pubmed-55734902017-09-27 Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis Turkoglu, Oya Emingul, Gulnur Eren, Gulnihal Atmaca, Harika Kutukculer, Necil Atilla, Gul J Istanb Univ Fac Dent Articles PURPOSE: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. MATERIALS AND METHODS: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. RESULTS: No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p<0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL-37 levels neither in healthy nor in gingivitis groups. CONCLUSION: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged. Istanbul University Faculty of Dentisty 2017-01-02 /pmc/articles/PMC5573490/ /pubmed/28955581 http://dx.doi.org/10.17096/jiufd.42354 Text en Copyright © 2017 Journal of Istanbul University Faculty of Dentistry This article is licensed under Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license ( (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the journal endorses its use. The material cannot be used for commercial purposes. If the user remixes, transforms, or builds upon the material, he/she may not distribute the modified material. No warranties are given. The license may not give the user all of the permissions necessary for his/her intended use. For example, other rights such as publicity, privacy, or moral rights may limit how the material can be used. |
spellingShingle | Articles Turkoglu, Oya Emingul, Gulnur Eren, Gulnihal Atmaca, Harika Kutukculer, Necil Atilla, Gul Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title | Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title_full | Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title_fullStr | Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title_full_unstemmed | Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title_short | Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
title_sort | levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573490/ https://www.ncbi.nlm.nih.gov/pubmed/28955581 http://dx.doi.org/10.17096/jiufd.42354 |
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