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Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [(14)C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers

PURPOSE: To determine the pharmacokinetics of radiolabeled copanlisib (BAY 80-6946) in healthy male volunteers and to investigate the disposition and biotransformation of copanlisib. METHODS: A single dose of 12 mg copanlisib containing 2.76 MBq [(14)C]copanlisib was administered as a 1-h intravenou...

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Detalles Bibliográficos
Autores principales:	Gerisch, Michael, Schwarz, Thomas, Lang, Dieter, Rohde, Gabriele, Reif, Stefanie, Genvresse, Isabelle, Reschke, Susanne, van der Mey, Dorina, Granvil, Camille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573760/ https://www.ncbi.nlm.nih.gov/pubmed/28714036 http://dx.doi.org/10.1007/s00280-017-3383-9

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