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Models to define the stages of articular cartilage degradation in osteoarthritis development
Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the differ...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573775/ https://www.ncbi.nlm.nih.gov/pubmed/28585282 http://dx.doi.org/10.1111/iep.12230 |
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author | Poulet, Blandine |
author_facet | Poulet, Blandine |
author_sort | Poulet, Blandine |
collection | PubMed |
description | Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary cartilage lesion area, timing of OA development in well‐described animal models and the versatility of a non‐invasive model of murine knee joint trauma. |
format | Online Article Text |
id | pubmed-5573775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55737752017-08-30 Models to define the stages of articular cartilage degradation in osteoarthritis development Poulet, Blandine Int J Exp Pathol Review Article Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary cartilage lesion area, timing of OA development in well‐described animal models and the versatility of a non‐invasive model of murine knee joint trauma. John Wiley and Sons Inc. 2017-06-05 2017-06 /pmc/articles/PMC5573775/ /pubmed/28585282 http://dx.doi.org/10.1111/iep.12230 Text en © 2017 The Authors. International Journal of Experimental Pathology published by John Wiley & Sons Ltd on behalf of Company of the International Journal of Experimental Pathology (CIJEP). This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Poulet, Blandine Models to define the stages of articular cartilage degradation in osteoarthritis development |
title | Models to define the stages of articular cartilage degradation in osteoarthritis development |
title_full | Models to define the stages of articular cartilage degradation in osteoarthritis development |
title_fullStr | Models to define the stages of articular cartilage degradation in osteoarthritis development |
title_full_unstemmed | Models to define the stages of articular cartilage degradation in osteoarthritis development |
title_short | Models to define the stages of articular cartilage degradation in osteoarthritis development |
title_sort | models to define the stages of articular cartilage degradation in osteoarthritis development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573775/ https://www.ncbi.nlm.nih.gov/pubmed/28585282 http://dx.doi.org/10.1111/iep.12230 |
work_keys_str_mv | AT pouletblandine modelstodefinethestagesofarticularcartilagedegradationinosteoarthritisdevelopment |