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Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Veterinary Science
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573824/ https://www.ncbi.nlm.nih.gov/pubmed/28690279 http://dx.doi.org/10.1292/jvms.17-0285 |
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author | NISHIKAWA, Yoshifumi |
author_facet | NISHIKAWA, Yoshifumi |
author_sort | NISHIKAWA, Yoshifumi |
collection | PubMed |
description | Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system. The research strategy taken in my laboratory will have strong potential to progress current understanding of the pathogenesis of N. caninum infection and promote development of a novel subunit vaccine based on the specific vaccine antigen with an antigen-delivery system for controlling neosporosis. |
format | Online Article Text |
id | pubmed-5573824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55738242017-08-29 Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum NISHIKAWA, Yoshifumi J Vet Med Sci Parasitology Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system. The research strategy taken in my laboratory will have strong potential to progress current understanding of the pathogenesis of N. caninum infection and promote development of a novel subunit vaccine based on the specific vaccine antigen with an antigen-delivery system for controlling neosporosis. The Japanese Society of Veterinary Science 2017-07-07 2017-08 /pmc/articles/PMC5573824/ /pubmed/28690279 http://dx.doi.org/10.1292/jvms.17-0285 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Parasitology NISHIKAWA, Yoshifumi Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum |
title | Towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with Neospora
caninum |
title_full | Towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with Neospora
caninum |
title_fullStr | Towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with Neospora
caninum |
title_full_unstemmed | Towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with Neospora
caninum |
title_short | Towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with Neospora
caninum |
title_sort | towards a preventive strategy for neosporosis: challenges and future
perspectives for vaccine development against infection with neospora
caninum |
topic | Parasitology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573824/ https://www.ncbi.nlm.nih.gov/pubmed/28690279 http://dx.doi.org/10.1292/jvms.17-0285 |
work_keys_str_mv | AT nishikawayoshifumi towardsapreventivestrategyforneosporosischallengesandfutureperspectivesforvaccinedevelopmentagainstinfectionwithneosporacaninum |