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Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum

Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against...

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Autor principal: NISHIKAWA, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573824/
https://www.ncbi.nlm.nih.gov/pubmed/28690279
http://dx.doi.org/10.1292/jvms.17-0285
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author NISHIKAWA, Yoshifumi
author_facet NISHIKAWA, Yoshifumi
author_sort NISHIKAWA, Yoshifumi
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description Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system. The research strategy taken in my laboratory will have strong potential to progress current understanding of the pathogenesis of N. caninum infection and promote development of a novel subunit vaccine based on the specific vaccine antigen with an antigen-delivery system for controlling neosporosis.
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spelling pubmed-55738242017-08-29 Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum NISHIKAWA, Yoshifumi J Vet Med Sci Parasitology Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system. The research strategy taken in my laboratory will have strong potential to progress current understanding of the pathogenesis of N. caninum infection and promote development of a novel subunit vaccine based on the specific vaccine antigen with an antigen-delivery system for controlling neosporosis. The Japanese Society of Veterinary Science 2017-07-07 2017-08 /pmc/articles/PMC5573824/ /pubmed/28690279 http://dx.doi.org/10.1292/jvms.17-0285 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Parasitology
NISHIKAWA, Yoshifumi
Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title_full Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title_fullStr Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title_full_unstemmed Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title_short Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum
title_sort towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with neospora caninum
topic Parasitology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573824/
https://www.ncbi.nlm.nih.gov/pubmed/28690279
http://dx.doi.org/10.1292/jvms.17-0285
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