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Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia
AIM: To examine the optimal absolute lymphocyte count (ALC) cut-off utilizing receiver operator characteristics (ROC) in addition to graft characteristics associated with early ALC recovery. METHODS: Patients who received T-cell replete peripheral hematopoietic cell transplantation (HCT) for acute l...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573899/ https://www.ncbi.nlm.nih.gov/pubmed/28900606 http://dx.doi.org/10.5500/wjt.v7.i4.235 |
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author | Damlaj, Moussab Ghazi, Samer Mashaqbeh, Walid Gmati, Gamal Salama, Hend Abuelgasim, Khadega A Rather, Mushtaq Hajeer, Ali Al-Zahrani, Mohsen Jazieh, Abdul-Rahman Alhejazi, Ayman Alaskar, Ahmed |
author_facet | Damlaj, Moussab Ghazi, Samer Mashaqbeh, Walid Gmati, Gamal Salama, Hend Abuelgasim, Khadega A Rather, Mushtaq Hajeer, Ali Al-Zahrani, Mohsen Jazieh, Abdul-Rahman Alhejazi, Ayman Alaskar, Ahmed |
author_sort | Damlaj, Moussab |
collection | PubMed |
description | AIM: To examine the optimal absolute lymphocyte count (ALC) cut-off utilizing receiver operator characteristics (ROC) in addition to graft characteristics associated with early ALC recovery. METHODS: Patients who received T-cell replete peripheral hematopoietic cell transplantation (HCT) for acute leukemia were identified. ALC cut-off was established using ROC analysis and subsequently the cohort was stratified. Time to endpoint analysis and cox regression modelling was computed to analyze outcomes. RESULTS: A total of 72 patients met the inclusion criteria and were analyzed. Optimal ALC cut-off was established to be on day 14 (D14) with ALC > 0.3 × 10(9)/L. At 2 years, cumulative incidence of relapse was 16.9% vs 46.9% (P = 0.025) for early and delayed lymphocyte recovery cohorts, respectively. Chronic graft vs host disease was more prevalent in the early lymphocyte recovery (ELR) group at 70% vs 27%, respectively (P = 0.0006). On multivariable analysis for relapse, ELR retained its prognostic significance with HR = 0.27 (0.05-0.94, P = 0.038). CONCLUSION: ELR is an independent predictor for relapse in patients receiving allogeneic HCT for acute leukemia. ELR was influenced by graft characteristics particularly CD34 count. |
format | Online Article Text |
id | pubmed-5573899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55738992017-09-12 Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia Damlaj, Moussab Ghazi, Samer Mashaqbeh, Walid Gmati, Gamal Salama, Hend Abuelgasim, Khadega A Rather, Mushtaq Hajeer, Ali Al-Zahrani, Mohsen Jazieh, Abdul-Rahman Alhejazi, Ayman Alaskar, Ahmed World J Transplant Observational Study AIM: To examine the optimal absolute lymphocyte count (ALC) cut-off utilizing receiver operator characteristics (ROC) in addition to graft characteristics associated with early ALC recovery. METHODS: Patients who received T-cell replete peripheral hematopoietic cell transplantation (HCT) for acute leukemia were identified. ALC cut-off was established using ROC analysis and subsequently the cohort was stratified. Time to endpoint analysis and cox regression modelling was computed to analyze outcomes. RESULTS: A total of 72 patients met the inclusion criteria and were analyzed. Optimal ALC cut-off was established to be on day 14 (D14) with ALC > 0.3 × 10(9)/L. At 2 years, cumulative incidence of relapse was 16.9% vs 46.9% (P = 0.025) for early and delayed lymphocyte recovery cohorts, respectively. Chronic graft vs host disease was more prevalent in the early lymphocyte recovery (ELR) group at 70% vs 27%, respectively (P = 0.0006). On multivariable analysis for relapse, ELR retained its prognostic significance with HR = 0.27 (0.05-0.94, P = 0.038). CONCLUSION: ELR is an independent predictor for relapse in patients receiving allogeneic HCT for acute leukemia. ELR was influenced by graft characteristics particularly CD34 count. Baishideng Publishing Group Inc 2017-08-24 2017-08-24 /pmc/articles/PMC5573899/ /pubmed/28900606 http://dx.doi.org/10.5500/wjt.v7.i4.235 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Observational Study Damlaj, Moussab Ghazi, Samer Mashaqbeh, Walid Gmati, Gamal Salama, Hend Abuelgasim, Khadega A Rather, Mushtaq Hajeer, Ali Al-Zahrani, Mohsen Jazieh, Abdul-Rahman Alhejazi, Ayman Alaskar, Ahmed Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title | Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title_full | Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title_fullStr | Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title_full_unstemmed | Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title_short | Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
title_sort | lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573899/ https://www.ncbi.nlm.nih.gov/pubmed/28900606 http://dx.doi.org/10.5500/wjt.v7.i4.235 |
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