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The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination

Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena inclu...

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Detalles Bibliográficos
Autores principales: Argunhan, Bilge, Murayama, Yasuto, Iwasaki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573924/
https://www.ncbi.nlm.nih.gov/pubmed/28423184
http://dx.doi.org/10.1002/1873-3468.12656
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author Argunhan, Bilge
Murayama, Yasuto
Iwasaki, Hiroshi
author_facet Argunhan, Bilge
Murayama, Yasuto
Iwasaki, Hiroshi
author_sort Argunhan, Bilge
collection PubMed
description Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5‐Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species.
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spelling pubmed-55739242017-09-15 The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination Argunhan, Bilge Murayama, Yasuto Iwasaki, Hiroshi FEBS Lett Review Articles Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5‐Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species. John Wiley and Sons Inc. 2017-05-08 2017-07 /pmc/articles/PMC5573924/ /pubmed/28423184 http://dx.doi.org/10.1002/1873-3468.12656 Text en © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Argunhan, Bilge
Murayama, Yasuto
Iwasaki, Hiroshi
The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title_full The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title_fullStr The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title_full_unstemmed The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title_short The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
title_sort differentiated and conserved roles of swi5‐sfr1 in homologous recombination
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573924/
https://www.ncbi.nlm.nih.gov/pubmed/28423184
http://dx.doi.org/10.1002/1873-3468.12656
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