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The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination
Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena inclu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573924/ https://www.ncbi.nlm.nih.gov/pubmed/28423184 http://dx.doi.org/10.1002/1873-3468.12656 |
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author | Argunhan, Bilge Murayama, Yasuto Iwasaki, Hiroshi |
author_facet | Argunhan, Bilge Murayama, Yasuto Iwasaki, Hiroshi |
author_sort | Argunhan, Bilge |
collection | PubMed |
description | Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5‐Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species. |
format | Online Article Text |
id | pubmed-5573924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55739242017-09-15 The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination Argunhan, Bilge Murayama, Yasuto Iwasaki, Hiroshi FEBS Lett Review Articles Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5‐Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species. John Wiley and Sons Inc. 2017-05-08 2017-07 /pmc/articles/PMC5573924/ /pubmed/28423184 http://dx.doi.org/10.1002/1873-3468.12656 Text en © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Argunhan, Bilge Murayama, Yasuto Iwasaki, Hiroshi The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title | The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title_full | The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title_fullStr | The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title_full_unstemmed | The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title_short | The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination |
title_sort | differentiated and conserved roles of swi5‐sfr1 in homologous recombination |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573924/ https://www.ncbi.nlm.nih.gov/pubmed/28423184 http://dx.doi.org/10.1002/1873-3468.12656 |
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