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A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia‐Lyases
Aromatic amino acid ammonia‐lyases and aromatic amino acid 2,3‐aminomutases contain the post‐translationally formed prosthetic 3,5‐dihydro‐4‐methylidene‐5H‐imidazol‐5‐one (MIO) group. MIO enzymes catalyze the stereoselective synthesis of α‐ or β‐amino acid enantiomers, making these chemical processe...
Autores principales: | Bata, Zsófia, Qian, Renzhe, Roller, Alexander, Horak, Jeannie, Bencze, László Csaba, Paizs, Csaba, Hammerschmidt, Friedrich, Vértessy, Beáta G., Poppe, László |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573973/ https://www.ncbi.nlm.nih.gov/pubmed/28919846 http://dx.doi.org/10.1002/adsc.201700428 |
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