Dose‐finding methods for Phase I clinical trials using pharmacokinetics in small populations

The aim of phase I clinical trials is to obtain reliable information on safety, tolerability, pharmacokinetics (PK), and mechanism of action of drugs with the objective of determining the maximum tolerated dose (MTD). In most phase I studies, dose‐finding and PK analysis are done separately and no a...

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Detalles Bibliográficos
Autores principales: Ursino, Moreno, Zohar, Sarah, Lentz, Frederike, Alberti, Corinne, Friede, Tim, Stallard, Nigel, Comets, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
General
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573988/
https://www.ncbi.nlm.nih.gov/pubmed/28321893
http://dx.doi.org/10.1002/bimj.201600084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573988/
https://www.ncbi.nlm.nih.gov/pubmed/28321893
http://dx.doi.org/10.1002/bimj.201600084

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