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Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies
Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574007/ https://www.ncbi.nlm.nih.gov/pubmed/28318047 http://dx.doi.org/10.1002/jor.23563 |
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author | Mueller, Alan J. Peffers, Mandy J. Proctor, Carole J. Clegg, Peter D. |
author_facet | Mueller, Alan J. Peffers, Mandy J. Proctor, Carole J. Clegg, Peter D. |
author_sort | Mueller, Alan J. |
collection | PubMed |
description | Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top‐down and bottom‐up approaches employed in the study of osteoarthritis. A holistic and multiscale approach, where clinical measurements may predict dysregulation and progression of joint degeneration, should be a key objective in future research. The review concludes with suggestions for further research and emerging trends not least of which is the coupled development of diagnostic tests and therapeutics as part of a concerted effort by the osteoarthritis research community to meet clinical needs. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 35:1573–1588, 2017. |
format | Online Article Text |
id | pubmed-5574007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55740072017-09-15 Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies Mueller, Alan J. Peffers, Mandy J. Proctor, Carole J. Clegg, Peter D. J Orthop Res Perspective Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top‐down and bottom‐up approaches employed in the study of osteoarthritis. A holistic and multiscale approach, where clinical measurements may predict dysregulation and progression of joint degeneration, should be a key objective in future research. The review concludes with suggestions for further research and emerging trends not least of which is the coupled development of diagnostic tests and therapeutics as part of a concerted effort by the osteoarthritis research community to meet clinical needs. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 35:1573–1588, 2017. John Wiley and Sons Inc. 2017-04-24 2017-08 /pmc/articles/PMC5574007/ /pubmed/28318047 http://dx.doi.org/10.1002/jor.23563 Text en © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Mueller, Alan J. Peffers, Mandy J. Proctor, Carole J. Clegg, Peter D. Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title | Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title_full | Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title_fullStr | Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title_full_unstemmed | Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title_short | Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies |
title_sort | systems approaches in osteoarthritis: identifying routes to novel diagnostic and therapeutic strategies |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574007/ https://www.ncbi.nlm.nih.gov/pubmed/28318047 http://dx.doi.org/10.1002/jor.23563 |
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