Cargando…

Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse

ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue‐reside...

Descripción completa

Detalles Bibliográficos
Autores principales: Hassnain Waqas, Syed F., Noble, Anna, Hoang, Anh C., Ampem, Grace, Popp, Manuela, Strauß, Sarah, Guille, Matthew, Röszer, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Leukocyte Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574031/
https://www.ncbi.nlm.nih.gov/pubmed/28642277
http://dx.doi.org/10.1189/jlb.1A0317-082RR
_version_ 1783259761943248896
author Hassnain Waqas, Syed F.
Noble, Anna
Hoang, Anh C.
Ampem, Grace
Popp, Manuela
Strauß, Sarah
Guille, Matthew
Röszer, Tamás
author_facet Hassnain Waqas, Syed F.
Noble, Anna
Hoang, Anh C.
Ampem, Grace
Popp, Manuela
Strauß, Sarah
Guille, Matthew
Röszer, Tamás
author_sort Hassnain Waqas, Syed F.
collection PubMed
description ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue‐resident Mϕs are capable of self‐renewal and develop from BM‐independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self‐renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
format Online
Article
Text
id pubmed-5574031
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Society for Leukocyte Biology
record_format MEDLINE/PubMed
spelling pubmed-55740312017-08-30 Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse Hassnain Waqas, Syed F. Noble, Anna Hoang, Anh C. Ampem, Grace Popp, Manuela Strauß, Sarah Guille, Matthew Röszer, Tamás J Leukoc Biol Cell Development, Differentiation, & Trafficking ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue‐resident Mϕs are capable of self‐renewal and develop from BM‐independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self‐renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development. Society for Leukocyte Biology 2017-06-22 2017-09 /pmc/articles/PMC5574031/ /pubmed/28642277 http://dx.doi.org/10.1189/jlb.1A0317-082RR Text en © 2017 Society for Leukocyte Biology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cell Development, Differentiation, & Trafficking
Hassnain Waqas, Syed F.
Noble, Anna
Hoang, Anh C.
Ampem, Grace
Popp, Manuela
Strauß, Sarah
Guille, Matthew
Röszer, Tamás
Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title_full Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title_fullStr Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title_full_unstemmed Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title_short Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse
title_sort adipose tissue macrophages develop from bone marrow–independent progenitors in xenopus laevis and mouse
topic Cell Development, Differentiation, & Trafficking
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574031/
https://www.ncbi.nlm.nih.gov/pubmed/28642277
http://dx.doi.org/10.1189/jlb.1A0317-082RR
work_keys_str_mv AT hassnainwaqassyedf adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT nobleanna adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT hoanganhc adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT ampemgrace adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT poppmanuela adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT straußsarah adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT guillematthew adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse
AT roszertamas adiposetissuemacrophagesdevelopfrombonemarrowindependentprogenitorsinxenopuslaevisandmouse