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The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells

Dishevelled (DVL) proteins are key mediators of the Wnt/β-catenin signaling pathway. All DVL proteins contain three conserved domains: DIX, PDZ, and DEP. There is a consensus in the field that the DIX domain is critical for Wnt/β-catenin signaling, but contradictory evidence regarding the function o...

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Detalles Bibliográficos
Autores principales: Paclíková, Petra, Bernatík, Ondřej, Radaszkiewicz, Tomasz Witold, Bryja, Vítězslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574038/
https://www.ncbi.nlm.nih.gov/pubmed/28674183
http://dx.doi.org/10.1128/MCB.00145-17