Cargando…

Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence

Rett syndrome (RTT) is a neurodevelopmental disorder with mutations in the MECP2 gene. Mostly girls are affected, and an apparently normal development is followed by cognitive impairment, motor dysfunction, epilepsy, and irregular breathing. Various indications suggest mitochondrial dysfunction. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bebensee, Dörthe F., Can, Karolina, Müller, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574314/ https://www.ncbi.nlm.nih.gov/pubmed/28894505 http://dx.doi.org/10.1155/2017/3064016

Ejemplares similares

Improving redox sensitivity of roGFP1 by incorporation of selenocysteine at position 147
por: Stanford, Katherine R., et al.
Publicado: (2018)

Local redox environment beneath biological membranes probed by palmitoylated-roGFP
por: Hatori, Yuta, et al.
Publicado: (2017)

Development of roGFP2-derived redox probes for measurement of the glutathione redox potential in the cytosol of severely glutathione-deficient rml1 seedlings
por: Aller, Isabel, et al.
Publicado: (2013)

A Bacterial Biosensor for Oxidative Stress Using the Constitutively Expressed Redox-Sensitive Protein roGFP2
por: Arias-Barreiro, Carlos R., et al.
Publicado: (2010)

Stable integration of the Mrx1-roGFP2 biosensor to monitor dynamic changes of the mycothiol redox potential in Corynebacterium glutamicum
por: Tung, Quach Ngoc, et al.
Publicado: (2018)

Method for measurement of bacillithiol redox potential changes using the Brx-roGFP2 redox biosensor in Staphylococcus aureus
por: Van Loi, Vu, et al.
Publicado: (2020)

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria
por: Keil, Vera C., et al.
Publicado: (2011)

Fluorescence spectroscopy of roGFP2-based redox probes responding to various physiologically relevant oxidant species in vitro
por: Müller, Alexandra, et al.
Publicado: (2017)

Assessing the regulation of leaf redox status under water stress conditions in Arabidopsis thaliana: Col-0 ecotype (wild-type and vtc-2), expressing mitochondrial and cytosolic roGFP1
por: Brossa, Ricard, et al.
Publicado: (2013)

Optimization of mito-roGFP protocol to measure mitochondrial oxidative status in human coronary artery endothelial cells
por: Teixeira, Rayane Brinck, et al.
Publicado: (2021)

Developing a cell-bound detection system for the screening of oxidase activity using the fluorescent peroxide sensor roGFP2-Orp1
por: Herzog, P L, et al.
Publicado: (2020)

A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria
por: Chandrasekharan, Aneesh, et al.
Publicado: (2018)

A High-Throughput Oxidative Stress Biosensor Based on Escherichia coli roGFP2 Cells Immobilized in a k-Carrageenan Matrix
por: Ooi, Lia, et al.
Publicado: (2015)

Expression of the H(2)O(2) Biosensor roGFP-Tpx1.C160S in Fission and Budding Yeasts and Jurkat Cells to Compare Intracellular H(2)O(2) Levels, Transmembrane Gradients, and Response to Metals
por: de Cubas, Laura, et al.
Publicado: (2023)

Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O(2) Consumption and ROS Release
por: Can, Karolina, et al.
Publicado: (2019)

Excitation and Inhibition Imbalance in Rett Syndrome
por: Li, Wei
Publicado: (2022)

Redox Imbalance and Morphological Changes in Skin Fibroblasts in Typical Rett Syndrome
por: Signorini, Cinzia, et al.
Publicado: (2014)

Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation
por: Festerling, Karina, et al.
Publicado: (2020)

Characterization and Dynamics of Aggresome Formation by a Cytosolic Gfp-Chimera✪
por: García-Mata, Rafael, et al.
Publicado: (1999)

Cytosolic Ca(2+) measurements by ratiometric fluorescence microscopy in melanoma cells
por: Rodrigues, Tiago, et al.
Publicado: (2021)

Red fluorescent redox-sensitive biosensor Grx1-roCherry
por: Shokhina, Arina G., et al.
Publicado: (2018)

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes
por: Dong, Qiping, et al.
Publicado: (2018)

Expression and Subcellular Distribution of GFP-Tagged Human Tetraspanin Proteins in Saccharomyces cerevisiae
por: Skaar, Karin, et al.
Publicado: (2015)

β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes
por: Watermann, Patrick, et al.
Publicado: (2023)

In Vivo Two-Photon Imaging of Astrocytes in GFAP-GFP Transgenic Mice
por: Guo, Dongjun, et al.
Publicado: (2017)

Characterization of Subcellular Organelles in Cortical Perisynaptic Astrocytes
por: Aboufares El Alaoui, Amina, et al.
Publicado: (2021)

Impaired CO(2) sensitivity of astrocytes in a mouse model of Rett syndrome
por: Turovsky, Egor, et al.
Publicado: (2015)

Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome
por: Rakela, Benjamin, et al.
Publicado: (2018)

Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control
por: Wang, Wei, et al.
Publicado: (2022)

Subcellular Dynamic Immunopatterning of Cytosolic Protein Complexes on Microstructured Polymer Substrates
por: Hager, Roland, et al.
Publicado: (2021)

Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation
por: Lester, Evan, et al.
Publicado: (2023)

Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
por: Barca‐Mayo, Olga, et al.
Publicado: (2019)

Rett and Rett‐like syndrome: Expanding the genetic spectrum to KIF1A and GRIN1 gene
por: Wang, Jiaping, et al.
Publicado: (2019)

Ratiometric Fluorescent Sensors Illuminate Cellular Magnesium Imbalance in a Model of Acetaminophen-Induced Liver Injury
por: Brady, Michael, et al.
Publicado: (2023)

IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients
por: Pini, Giorgio, et al.
Publicado: (2012)

Novel FOXG1 mutations in Chinese patients with Rett syndrome or Rett-like mental retardation
por: Zhang, Qingping, et al.
Publicado: (2017)

Imbalance between Glutamate and GABA in Fmr1 Knockout Astrocytes Influences Neuronal Development
por: Wang, Lu, et al.
Publicado: (2016)

Accelerated aging in mice with astrocytic redox imbalance as a consequence of SOD2 deletion
por: Tsesmelis, Konstantinos, et al.
Publicado: (2023)

Differential production rates of cytosolic and transmembrane GFP reporters in C. elegans L3 larval uterine cells
por: Kenny-Ganzert, Isabel, et al.
Publicado: (2023)

From ZeRO to HeRO: Saving lives one HeRO at a time
por: Ratcliff, Dr. Charlotte, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5j0lc8s6kqi1bqlvmh104qdvun