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Anti-Apoptotic Effects of Osteopontin via the Up-Regulation of AKT/mTOR/β-Catenin Loop in Acute Myeloid Leukemia Cells

Background: The conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (AML) mostly target tumor bulk but not leukemic stem cells (LSCs). Aberrant expression or activation of mediators such as osteopontin (OPN) or PI3K/PTEN/Akt/mTOR pathway plays a key role in m...

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Detalles Bibliográficos
Autores principales:	Zahed Panah, Mahdi, Nikbakht, Mohsen, Sajjadi, Seyed Mehdi, Rostami, Shahrbano, Norooznezhad, Amir Hossein, Kamranzadeh Fumani, Hosein, Ghavamzadeh, Ardeshir, Mohammadi, Saeed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574411/ https://www.ncbi.nlm.nih.gov/pubmed/28875010

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