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No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA

OBJECTIVE: The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. HLA-B27 positivity is possibly associated with severity of ankylosis. We studied the in vitro and in vivo impact of HLA-B27 in models of chondrogenesis and osteogenesis. METHODS: Di...

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Detalles Bibliográficos
Autores principales:	Neerinckx, Barbara, Kollnberger, Simon, Shaw, Jacqueline, Lories, Rik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Spondyloarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574451/ https://www.ncbi.nlm.nih.gov/pubmed/28879048 http://dx.doi.org/10.1136/rmdopen-2017-000451

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