The stability of Fbw7α in M-phase requires its phosphorylation by PKC

Fbw7 is a tumor suppressor often deleted or mutated in human cancers. It serves as the substrate-recruiting subunit of a SCF ubiquitin ligase that targets numerous critical proteins for degradation, including oncoproteins and master transcription factors. Cyclin E was the first identified substrate...

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Detalles Bibliográficos
Autores principales: Zitouni, Sihem, Méchali, Francisca, Papin, Catherine, Choquet, Armelle, Roche, Daniel, Baldin, Véronique, Coux, Olivier, Bonne-Andrea, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574586/
https://www.ncbi.nlm.nih.gov/pubmed/28850619
http://dx.doi.org/10.1371/journal.pone.0183500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574586/
https://www.ncbi.nlm.nih.gov/pubmed/28850619
http://dx.doi.org/10.1371/journal.pone.0183500

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