Cargando…
Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis
OBJECTIVE: Increasing evidence suggest that neuronal damage is an early and diffuse feature of Multiple Sclerosis (MS) pathology. Analysis of the optic pathway may help to clarify the mechanisms involved in grey matter damage in MS. Purpose of our study was to investigate the relationship between in...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574611/ https://www.ncbi.nlm.nih.gov/pubmed/28850630 http://dx.doi.org/10.1371/journal.pone.0183957 |
_version_ | 1783259876126883840 |
---|---|
author | Puthenparampil, Marco Federle, Lisa Poggiali, Davide Miante, Silvia Signori, Alessio Pilotto, Elisabetta Rinaldi, Francesca Perini, Paola Sormani, Maria Pia Midena, Edoardo Gallo, Paolo |
author_facet | Puthenparampil, Marco Federle, Lisa Poggiali, Davide Miante, Silvia Signori, Alessio Pilotto, Elisabetta Rinaldi, Francesca Perini, Paola Sormani, Maria Pia Midena, Edoardo Gallo, Paolo |
author_sort | Puthenparampil, Marco |
collection | PubMed |
description | OBJECTIVE: Increasing evidence suggest that neuronal damage is an early and diffuse feature of Multiple Sclerosis (MS) pathology. Analysis of the optic pathway may help to clarify the mechanisms involved in grey matter damage in MS. Purpose of our study was to investigate the relationship between inflammation and neurodegeneration and to achieve evidence of trans-synaptic degeneration in the optic pathway in MS at clinical onset. METHODS: 50 clinically isolated syndromes/early relapse-onset MS (CIS/eRRMS) with mean disease duration of 4.0±3.5 months, 28 MRI healthy controls (HC) and 31 OCT-HC were studied. Ten patients had optic neuritis at presentation (MSON+), 40 presented with other symptoms (MSON-). MRI examination included 3D-T1, 3D-FLAIR and 3D-DIR sequences. Global cortical thickness (gCTh), pericalcarin CTh (pCTh) and white matter volume (WMV) were analysed by means of Freesurfer on 3D-T1 scans. Optic radiation morphology (OR) and volume (ORV) were reconstructed on the base of the Jülich’s Atlas. White matter lesion volume (WMLV), OR-WMLV and percent WM damage (WMLV/WMV = WMLV% and OR-WMLV/ORV = ORWMLV%) were obtained by 3D-FLAIR image segmentation. 3D-DIR sequences were applied to identify inflammatory lesions of the optic nerve. Optic coherence tomography (OCT) protocol included the analysis of global peripapillary retinal nerve fiber layer (g-RNFL) and the 6 fundus oculi’s sectors (temporal, T-RNFL; temporal superior, TS-RNFL; nasal superior, NS-RNFL; nasal, N-RNFL; nasal inferior, NI-RNFL, temporal inferior, TI-RNFL). The retina of both eyes was analyzed. The eyes of ON+ were further divided into affected (aON+) or not (naON+). RESULTS: No difference in CTh was found between CIS/eRRMS and HC, and between MSON+ and MSON-. Moreover, MSON+ and MSON- did not differ for any WM lesion load parameter. The most significant correlations between RNFL thickness and optic radiation WM pathology were found in MSON+. In these patients, the temporal RNFL inversely correlated to ipsilateral optic radiation WM lesion load (T-RNFL: r -0.7, p<0.05; TS-RNFL: r -0.7, p<0.05), while nasal RNFL inversely correlated to contralateral optic radiation WM lesion load (NI: r -0.8, p<0.01; NS-RNFL: r -0.8, p<0.01). CONCLUSIONS: Our findings suggest that in MSON+ the optic pathway is site of a diffuse pathological process that involves both directly and via trans-synaptic degeneration the RNFL. |
format | Online Article Text |
id | pubmed-5574611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55746112017-09-15 Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis Puthenparampil, Marco Federle, Lisa Poggiali, Davide Miante, Silvia Signori, Alessio Pilotto, Elisabetta Rinaldi, Francesca Perini, Paola Sormani, Maria Pia Midena, Edoardo Gallo, Paolo PLoS One Research Article OBJECTIVE: Increasing evidence suggest that neuronal damage is an early and diffuse feature of Multiple Sclerosis (MS) pathology. Analysis of the optic pathway may help to clarify the mechanisms involved in grey matter damage in MS. Purpose of our study was to investigate the relationship between inflammation and neurodegeneration and to achieve evidence of trans-synaptic degeneration in the optic pathway in MS at clinical onset. METHODS: 50 clinically isolated syndromes/early relapse-onset MS (CIS/eRRMS) with mean disease duration of 4.0±3.5 months, 28 MRI healthy controls (HC) and 31 OCT-HC were studied. Ten patients had optic neuritis at presentation (MSON+), 40 presented with other symptoms (MSON-). MRI examination included 3D-T1, 3D-FLAIR and 3D-DIR sequences. Global cortical thickness (gCTh), pericalcarin CTh (pCTh) and white matter volume (WMV) were analysed by means of Freesurfer on 3D-T1 scans. Optic radiation morphology (OR) and volume (ORV) were reconstructed on the base of the Jülich’s Atlas. White matter lesion volume (WMLV), OR-WMLV and percent WM damage (WMLV/WMV = WMLV% and OR-WMLV/ORV = ORWMLV%) were obtained by 3D-FLAIR image segmentation. 3D-DIR sequences were applied to identify inflammatory lesions of the optic nerve. Optic coherence tomography (OCT) protocol included the analysis of global peripapillary retinal nerve fiber layer (g-RNFL) and the 6 fundus oculi’s sectors (temporal, T-RNFL; temporal superior, TS-RNFL; nasal superior, NS-RNFL; nasal, N-RNFL; nasal inferior, NI-RNFL, temporal inferior, TI-RNFL). The retina of both eyes was analyzed. The eyes of ON+ were further divided into affected (aON+) or not (naON+). RESULTS: No difference in CTh was found between CIS/eRRMS and HC, and between MSON+ and MSON-. Moreover, MSON+ and MSON- did not differ for any WM lesion load parameter. The most significant correlations between RNFL thickness and optic radiation WM pathology were found in MSON+. In these patients, the temporal RNFL inversely correlated to ipsilateral optic radiation WM lesion load (T-RNFL: r -0.7, p<0.05; TS-RNFL: r -0.7, p<0.05), while nasal RNFL inversely correlated to contralateral optic radiation WM lesion load (NI: r -0.8, p<0.01; NS-RNFL: r -0.8, p<0.01). CONCLUSIONS: Our findings suggest that in MSON+ the optic pathway is site of a diffuse pathological process that involves both directly and via trans-synaptic degeneration the RNFL. Public Library of Science 2017-08-29 /pmc/articles/PMC5574611/ /pubmed/28850630 http://dx.doi.org/10.1371/journal.pone.0183957 Text en © 2017 Puthenparampil et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Puthenparampil, Marco Federle, Lisa Poggiali, Davide Miante, Silvia Signori, Alessio Pilotto, Elisabetta Rinaldi, Francesca Perini, Paola Sormani, Maria Pia Midena, Edoardo Gallo, Paolo Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title | Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title_full | Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title_fullStr | Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title_full_unstemmed | Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title_short | Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
title_sort | trans-synaptic degeneration in the optic pathway. a study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574611/ https://www.ncbi.nlm.nih.gov/pubmed/28850630 http://dx.doi.org/10.1371/journal.pone.0183957 |
work_keys_str_mv | AT puthenparampilmarco transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT federlelisa transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT poggialidavide transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT miantesilvia transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT signorialessio transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT pilottoelisabetta transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT rinaldifrancesca transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT perinipaola transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT sormanimariapia transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT midenaedoardo transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis AT gallopaolo transsynapticdegenerationintheopticpathwayastudyinclinicallyisolatedsyndromeandearlyrelapsingremittingmultiplesclerosiswithorwithoutopticneuritis |