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Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans

BACKGROUND: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation studies suggested that acute application of selective noradrenaline reuptake inhibitors enhanc...

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Autores principales: Kuo, Hsiao-I, Paulus, Walter, Batsikadze, Giorgi, Jamil, Asif, Kuo, Min-Fang, Nitsche, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574667/
https://www.ncbi.nlm.nih.gov/pubmed/28430976
http://dx.doi.org/10.1093/ijnp/pyx026
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author Kuo, Hsiao-I
Paulus, Walter
Batsikadze, Giorgi
Jamil, Asif
Kuo, Min-Fang
Nitsche, Michael A
author_facet Kuo, Hsiao-I
Paulus, Walter
Batsikadze, Giorgi
Jamil, Asif
Kuo, Min-Fang
Nitsche, Michael A
author_sort Kuo, Hsiao-I
collection PubMed
description BACKGROUND: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation studies suggested that acute application of selective noradrenaline reuptake inhibitors enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged noradrenaline reuptake inhibitor treatment, which might go along with different physiological effects. METHODS: The purpose of this study was to investigate the acute and chronic effects of the selective noradrenaline reuptake inhibitor reboxetine on cortical excitability in healthy humans in a double-blind, placebo-controlled, randomized crossover study. Sixteen subjects were assessed with different transcranial magnetic stimulation measurements: motor thresholds, input-output curve, short-latency intracortical inhibition and intracortical facilitation, I-wave facilitation, and short-interval afferent inhibition before and after placebo or reboxetine (8 mg) single-dose administration. Afterwards, the same subjects took reboxetine (8 mg/d) consecutively for 21 days. During this period (subjects underwent 2 experimental sessions with identical transcranial magnetic stimulation measures under placebo or reboxetine), transcranial magnetic stimulation measurements were assessed before and after drug intake. RESULTS: Both single-dose and chronic administration of reboxetine increased cortical excitability; increased the slope of the input-output curve, intracortical facilitation, and I-wave facilitation; but decreased short-latency intracortical inhibition and short-interval afferent inhibition. Moreover, chronic reboxetine showed a larger enhancement of intracortical facilitation and I-wave facilitation compared with single-dose application. CONCLUSIONS: The results show physiological mechanisms of noradrenergic enhancement possibly underlying the functional effects of reboxetine regarding acute and chronic application.
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spelling pubmed-55746672017-09-05 Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans Kuo, Hsiao-I Paulus, Walter Batsikadze, Giorgi Jamil, Asif Kuo, Min-Fang Nitsche, Michael A Int J Neuropsychopharmacol Regular Research Articles BACKGROUND: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation studies suggested that acute application of selective noradrenaline reuptake inhibitors enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged noradrenaline reuptake inhibitor treatment, which might go along with different physiological effects. METHODS: The purpose of this study was to investigate the acute and chronic effects of the selective noradrenaline reuptake inhibitor reboxetine on cortical excitability in healthy humans in a double-blind, placebo-controlled, randomized crossover study. Sixteen subjects were assessed with different transcranial magnetic stimulation measurements: motor thresholds, input-output curve, short-latency intracortical inhibition and intracortical facilitation, I-wave facilitation, and short-interval afferent inhibition before and after placebo or reboxetine (8 mg) single-dose administration. Afterwards, the same subjects took reboxetine (8 mg/d) consecutively for 21 days. During this period (subjects underwent 2 experimental sessions with identical transcranial magnetic stimulation measures under placebo or reboxetine), transcranial magnetic stimulation measurements were assessed before and after drug intake. RESULTS: Both single-dose and chronic administration of reboxetine increased cortical excitability; increased the slope of the input-output curve, intracortical facilitation, and I-wave facilitation; but decreased short-latency intracortical inhibition and short-interval afferent inhibition. Moreover, chronic reboxetine showed a larger enhancement of intracortical facilitation and I-wave facilitation compared with single-dose application. CONCLUSIONS: The results show physiological mechanisms of noradrenergic enhancement possibly underlying the functional effects of reboxetine regarding acute and chronic application. Oxford University Press 2017-04-19 /pmc/articles/PMC5574667/ /pubmed/28430976 http://dx.doi.org/10.1093/ijnp/pyx026 Text en © The Author 2017. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Research Articles
Kuo, Hsiao-I
Paulus, Walter
Batsikadze, Giorgi
Jamil, Asif
Kuo, Min-Fang
Nitsche, Michael A
Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title_full Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title_fullStr Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title_full_unstemmed Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title_short Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans
title_sort acute and chronic noradrenergic effects on cortical excitability in healthy humans
topic Regular Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574667/
https://www.ncbi.nlm.nih.gov/pubmed/28430976
http://dx.doi.org/10.1093/ijnp/pyx026
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