A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

BPIFB4 is associated with exceptional longevity: four single-nucleotide polymorphisms distinguish the wild-type form from a longevity-associated variant conferring positive effects on blood pressure. The effect of a rare variant (RV; allele frequency, 4%) on blood pressure is unknown. Here, we show...

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Detalles Bibliográficos
Autores principales: Vecchione, Carmine, Villa, Francesco, Carrizzo, Albino, Spinelli, Chiara Carmela, Damato, Antonio, Ambrosio, Mariateresa, Ferrario, Anna, Madonna, Michele, Uccellatore, Annachiara, Lupini, Silvia, Maciag, Anna, Ryskalin, Larisa, Milanesi, Luciano, Frati, Giacomo, Sciarretta, Sebastiano, Bellazzi, Riccardo, Genovese, Stefano, Ceriello, Antonio, Auricchio, Alberto, Malovini, Alberto, Puca, Annibale Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574984/
https://www.ncbi.nlm.nih.gov/pubmed/28852218
http://dx.doi.org/10.1038/s41598-017-10341-x

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