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The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers a...

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Autores principales: de Carvalho, Aline Martins, Shao, Ping, Liu, Huikun, Cheng, Han-Ling, Zheng, Yan, Leng, Junhong, Li, Weiqin, Huang, Tao, Wang, Tiange, Wang, Leishen, Zhang, Shuang, Hu, Gang, Qi, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575005/
https://www.ncbi.nlm.nih.gov/pubmed/28852042
http://dx.doi.org/10.1038/s41598-017-10101-x
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author de Carvalho, Aline Martins
Shao, Ping
Liu, Huikun
Cheng, Han-Ling
Zheng, Yan
Leng, Junhong
Li, Weiqin
Huang, Tao
Wang, Tiange
Wang, Leishen
Zhang, Shuang
Hu, Gang
Qi, Lu
author_facet de Carvalho, Aline Martins
Shao, Ping
Liu, Huikun
Cheng, Han-Ling
Zheng, Yan
Leng, Junhong
Li, Weiqin
Huang, Tao
Wang, Tiange
Wang, Leishen
Zhang, Shuang
Hu, Gang
Qi, Lu
author_sort de Carvalho, Aline Martins
collection PubMed
description The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. The adiposity-increasing allele (C) of the MC4R variant rs6567160 was associated with greater postpartum increase of HbA1c (β = 0.08%; P = 0.03) and 2-hour OGTT glucose concentrations (β = 0.25 mmol/L; P = 0.02). In addition, we found an interaction between the MC4R genotype and postpartum weight reduction on changes in fasting plasma glucose (P-interaction = 0.03). We found that the MC4R genotype was associated with postpartum glycemic changes; and the association with fasting glucose were significantly modified by postpartum weight reduction in women who had experienced GDM.
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spelling pubmed-55750052017-09-01 The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis de Carvalho, Aline Martins Shao, Ping Liu, Huikun Cheng, Han-Ling Zheng, Yan Leng, Junhong Li, Weiqin Huang, Tao Wang, Tiange Wang, Leishen Zhang, Shuang Hu, Gang Qi, Lu Sci Rep Article The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. The adiposity-increasing allele (C) of the MC4R variant rs6567160 was associated with greater postpartum increase of HbA1c (β = 0.08%; P = 0.03) and 2-hour OGTT glucose concentrations (β = 0.25 mmol/L; P = 0.02). In addition, we found an interaction between the MC4R genotype and postpartum weight reduction on changes in fasting plasma glucose (P-interaction = 0.03). We found that the MC4R genotype was associated with postpartum glycemic changes; and the association with fasting glucose were significantly modified by postpartum weight reduction in women who had experienced GDM. Nature Publishing Group UK 2017-08-29 /pmc/articles/PMC5575005/ /pubmed/28852042 http://dx.doi.org/10.1038/s41598-017-10101-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
de Carvalho, Aline Martins
Shao, Ping
Liu, Huikun
Cheng, Han-Ling
Zheng, Yan
Leng, Junhong
Li, Weiqin
Huang, Tao
Wang, Tiange
Wang, Leishen
Zhang, Shuang
Hu, Gang
Qi, Lu
The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title_full The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title_fullStr The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title_full_unstemmed The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title_short The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
title_sort mc4r genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575005/
https://www.ncbi.nlm.nih.gov/pubmed/28852042
http://dx.doi.org/10.1038/s41598-017-10101-x
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