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The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575005/ https://www.ncbi.nlm.nih.gov/pubmed/28852042 http://dx.doi.org/10.1038/s41598-017-10101-x |
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author | de Carvalho, Aline Martins Shao, Ping Liu, Huikun Cheng, Han-Ling Zheng, Yan Leng, Junhong Li, Weiqin Huang, Tao Wang, Tiange Wang, Leishen Zhang, Shuang Hu, Gang Qi, Lu |
author_facet | de Carvalho, Aline Martins Shao, Ping Liu, Huikun Cheng, Han-Ling Zheng, Yan Leng, Junhong Li, Weiqin Huang, Tao Wang, Tiange Wang, Leishen Zhang, Shuang Hu, Gang Qi, Lu |
author_sort | de Carvalho, Aline Martins |
collection | PubMed |
description | The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. The adiposity-increasing allele (C) of the MC4R variant rs6567160 was associated with greater postpartum increase of HbA1c (β = 0.08%; P = 0.03) and 2-hour OGTT glucose concentrations (β = 0.25 mmol/L; P = 0.02). In addition, we found an interaction between the MC4R genotype and postpartum weight reduction on changes in fasting plasma glucose (P-interaction = 0.03). We found that the MC4R genotype was associated with postpartum glycemic changes; and the association with fasting glucose were significantly modified by postpartum weight reduction in women who had experienced GDM. |
format | Online Article Text |
id | pubmed-5575005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55750052017-09-01 The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis de Carvalho, Aline Martins Shao, Ping Liu, Huikun Cheng, Han-Ling Zheng, Yan Leng, Junhong Li, Weiqin Huang, Tao Wang, Tiange Wang, Leishen Zhang, Shuang Hu, Gang Qi, Lu Sci Rep Article The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. The adiposity-increasing allele (C) of the MC4R variant rs6567160 was associated with greater postpartum increase of HbA1c (β = 0.08%; P = 0.03) and 2-hour OGTT glucose concentrations (β = 0.25 mmol/L; P = 0.02). In addition, we found an interaction between the MC4R genotype and postpartum weight reduction on changes in fasting plasma glucose (P-interaction = 0.03). We found that the MC4R genotype was associated with postpartum glycemic changes; and the association with fasting glucose were significantly modified by postpartum weight reduction in women who had experienced GDM. Nature Publishing Group UK 2017-08-29 /pmc/articles/PMC5575005/ /pubmed/28852042 http://dx.doi.org/10.1038/s41598-017-10101-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article de Carvalho, Aline Martins Shao, Ping Liu, Huikun Cheng, Han-Ling Zheng, Yan Leng, Junhong Li, Weiqin Huang, Tao Wang, Tiange Wang, Leishen Zhang, Shuang Hu, Gang Qi, Lu The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title | The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title_full | The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title_fullStr | The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title_full_unstemmed | The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title_short | The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
title_sort | mc4r genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575005/ https://www.ncbi.nlm.nih.gov/pubmed/28852042 http://dx.doi.org/10.1038/s41598-017-10101-x |
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