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Multifunctional quantum dot DNA hydrogels

Biotemplated nanomaterials offer versatile functionality for multimodal imaging, biosensing, and drug delivery. There remains an unmet need for traceable and biocompatible nanomaterials that can be synthesized in a precisely controllable manner. Here, we report self-assembled quantum dot DNA hydroge...

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Autores principales: Zhang, Libing, Jean, Sae Rin, Ahmed, Sharif, Aldridge, Peter M., Li, Xiyan, Fan, Fengjia, Sargent, Edward H., Kelley, Shana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575008/
https://www.ncbi.nlm.nih.gov/pubmed/28851869
http://dx.doi.org/10.1038/s41467-017-00298-w
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author Zhang, Libing
Jean, Sae Rin
Ahmed, Sharif
Aldridge, Peter M.
Li, Xiyan
Fan, Fengjia
Sargent, Edward H.
Kelley, Shana O.
author_facet Zhang, Libing
Jean, Sae Rin
Ahmed, Sharif
Aldridge, Peter M.
Li, Xiyan
Fan, Fengjia
Sargent, Edward H.
Kelley, Shana O.
author_sort Zhang, Libing
collection PubMed
description Biotemplated nanomaterials offer versatile functionality for multimodal imaging, biosensing, and drug delivery. There remains an unmet need for traceable and biocompatible nanomaterials that can be synthesized in a precisely controllable manner. Here, we report self-assembled quantum dot DNA hydrogels that exhibit both size and spectral tunability. We successfully incorporate DNA-templated quantum dots with high quantum yield, long-term photostability, and low cytotoxicity into a hydrogel network in a single step. By leveraging DNA-guided interactions, we introduce multifunctionality for a variety of applications, including enzyme-responsive drug delivery and cell-specific targeting. We report that quantum dot DNA hydrogels can be used for delivery of doxorubicin, an anticancer drug, to increase potency 9-fold against cancer cells. This approach also demonstrated high biocompatibility, trackability, and in vivo therapeutic efficacy in mice bearing xenografted breast cancer tumors. This work paves the way for the development of new tunable biotemplated nanomaterials with multiple synergistic functionalities for biomedical applications.
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spelling pubmed-55750082017-09-01 Multifunctional quantum dot DNA hydrogels Zhang, Libing Jean, Sae Rin Ahmed, Sharif Aldridge, Peter M. Li, Xiyan Fan, Fengjia Sargent, Edward H. Kelley, Shana O. Nat Commun Article Biotemplated nanomaterials offer versatile functionality for multimodal imaging, biosensing, and drug delivery. There remains an unmet need for traceable and biocompatible nanomaterials that can be synthesized in a precisely controllable manner. Here, we report self-assembled quantum dot DNA hydrogels that exhibit both size and spectral tunability. We successfully incorporate DNA-templated quantum dots with high quantum yield, long-term photostability, and low cytotoxicity into a hydrogel network in a single step. By leveraging DNA-guided interactions, we introduce multifunctionality for a variety of applications, including enzyme-responsive drug delivery and cell-specific targeting. We report that quantum dot DNA hydrogels can be used for delivery of doxorubicin, an anticancer drug, to increase potency 9-fold against cancer cells. This approach also demonstrated high biocompatibility, trackability, and in vivo therapeutic efficacy in mice bearing xenografted breast cancer tumors. This work paves the way for the development of new tunable biotemplated nanomaterials with multiple synergistic functionalities for biomedical applications. Nature Publishing Group UK 2017-08-29 /pmc/articles/PMC5575008/ /pubmed/28851869 http://dx.doi.org/10.1038/s41467-017-00298-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Libing
Jean, Sae Rin
Ahmed, Sharif
Aldridge, Peter M.
Li, Xiyan
Fan, Fengjia
Sargent, Edward H.
Kelley, Shana O.
Multifunctional quantum dot DNA hydrogels
title Multifunctional quantum dot DNA hydrogels
title_full Multifunctional quantum dot DNA hydrogels
title_fullStr Multifunctional quantum dot DNA hydrogels
title_full_unstemmed Multifunctional quantum dot DNA hydrogels
title_short Multifunctional quantum dot DNA hydrogels
title_sort multifunctional quantum dot dna hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575008/
https://www.ncbi.nlm.nih.gov/pubmed/28851869
http://dx.doi.org/10.1038/s41467-017-00298-w
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